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Product Details
PA5-19886
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to amino acids 25 to 40 of human DR3 precusor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155237
Product Specific Information
In Western blot applications, this antibody detects a band at ~59kDa. A suggested positive control is Jurkat cell lysate.
PA5-19886 can be used with blocking peptide PEP-0015.
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-3; apoptosis inducing receptor; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; Death receptor 3; death receptor beta; LARD; Lymphocyte-associated receptor of death; Protein WSL; Protein WSL-1; RP4-650H14.2; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein); tumor necrosis factor receptor superfamily, member 25
Gene Aliases: APO-3; APO3; DDR3; DR3; LARD; TNFRSF12; TNFRSF25; TR3; TRAMP; UNQ455/PRO779; WSL; WSL-1; WSL-LR; WSL1
UniProt ID: (Human) Q93038
Entrez Gene ID: (Human) 8718, (Mouse) 85030
apoptotic process
inflammatory response
immune response
signal transduction
cell surface receptor signaling pathway
multicellular organism development
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
regulation of apoptotic process
positive regulation of MAPK cascade
apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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