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Invitrogen
DTX3L Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
DTX3L Antibody (720394) in WB
Western blot analysis was performed on Whole cell extracts (30 µg lysate) of PC-3 (Lane 1), DU 145 (Lane 2), LNCaP (Lane 3), HeLa (Lane 4), MCF-7 (Lane 5), A-431 (Lane 6), HT-29 (Lane 7) and K-562 (Lane 8). The blots were probed with Anti-DTX3L Rabbit Polyclonal Antibody (Product # 720394, 2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.2 µg/mL, 1:5000 dilution). A 83 kDa band corresponding to DTX3L was observed across the cell lines tes... View More
Product Details
720394
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to human DTX3L [1) aa709-aa728 2) aa194-aa213]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723101
Product Specific Information
This antibody is predicted to react with Monkey, Bovine, Pig, Cat.
Target Information
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-lymphoma- and BAL-associated protein; deltex 3 like, E3 ubiquitin ligase; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; rhysin 2; Rhysin-2; Rhysin2; RING-type E3 ubiquitin transferase DTX3L
Gene Aliases: BBAP; DTX3L
UniProt ID: (Human) Q8TDB6
Entrez Gene ID: (Human) 151636
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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