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Product Details
PA5-82621
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DUSP26. Recombinant protein control fragment (Product #RP-91560).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2789778
Product Specific Information
Immunogen sequence: CPGNWLWASM TFMARFSRSS SRSPVRTRGT LEEMPTVQHP FLNVFELERL LYTGKTACNH ADEVWPGLYL GDQDMANNRR ELRRLGITHV L
Target Information
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DSP-4; Dual specificity phosphatase SKRP3; Dual specificity protein phosphatase 26; Low-molecular-mass dual-specificity phosphatase 4; MAP kinase phosphatase 8; MGC1136; MGC2627; Mitogen-activated protein kinase phosphatase 8; neuroendocrine-associated phosphatase; Novel amplified gene in thyroid anaplastic cancer
Gene Aliases: DSP-4; DUSP24; DUSP26; LDP-4; LDP4; MKP-8; MKP8; NATA1; NEAP; SKRP3
UniProt ID: (Human) Q9BV47
Entrez Gene ID: (Human) 78986
negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
peptidyl-tyrosine dephosphorylation
negative regulation of protein kinase activity by regulation of protein phosphorylation
positive regulation of cell adhesion
negative regulation of ERK1 and ERK2 cascade
positive regulation of peptidyl-serine dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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