Proteintech

DVL2 Polyclonal Antibody

DVL2 Antibody in Immunocytochemistry (ICC/IF)

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DVL2 Antibody (12037-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 12037-1-AP (DVL2 antibody) at dilution of 1:50 and Rhodamine-Goat anti-Rabbit IGG.

DVL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

DVL2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12037-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat, Xenopus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

DVL2 Fusion Protein Ag2666 (1-340 aa encoded by BC014844)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAGSSTGGG GVGETKVIYH LDEEETPYLV KIPVPAERIT LGDFKSVLQR PAGAKYFFKS MDQDFGVVKE EISDDNARLP CFNGRVVSWL VSSDNPQPEM APPVHEPRAE LAPPAPPLPP LPPERTSGIG DSRPPSFHPN VSSSHENLEP ETETESVVSL RRERPRRRDS SEHGAGGHRT GGPSRLERHL AGYESSSTLM TSELESTSLG DSDEEDTMSR FSSSTEQSSA SRLLKRHRRR RKQRPPRLER TSSFSSVTDS TMSLNIITVT LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ VNDMNFENMS NDDAVRVLRD I (1-340 aa encoded by BC014844)

Target Information

Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Neuroprotective effects of oxymatrine on hypoxic-ischemic brain damage in neonatal rats by activating the Wnt/β-catenin pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lan XB,Ni YS,Liu N,Wei W,Liu Y,Yang JM,Ma L,Bai R,Zhang J,Yu JQ

Wed Mar 01 00:00:00 EST 2023

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

Food & function

Fang J,Zhang Z,Cheng Y,Yang H,Zhang H,Xue Z,Lu S,Dong Y,Song C,Zhang X,Zhou Y

Wed Apr 20 00:00:00 EDT 2022

High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis.

BMC medical genomics

Zhang G,Liu B,Shang H,Wu G,Wu D,Wang L,Li S,Wang Z,Wang S,Yuan J

Mon Aug 15 00:00:00 EDT 2022

CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/β-catenin pathway.

Biochemical and biophysical research communications

Zhang X,Tian L,Li Z,Liu R,Yu J,Liu B

Thu Oct 20 00:00:00 EDT 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xu W,Du X,Li J,Zhang Z,Ma X,Luo D,Xiao M,Sun Q

Sun May 01 00:00:00 EDT 2022

Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun M,Gao J,Meng T,Liu S,Chen H,Liu Q,Xing X,Zhao C,Luo Y

Mon Feb 01 00:00:00 EST 2021

Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Sun M,Gao J,Meng T,Liu S,Chen H,Liu Q,Xing X,Zhao C,Luo Y

Mon Feb 01 00:00:00 EST 2021

Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.

Food & function

Zhang Z,Xue Z,Yang H,Zhao F,Liu C,Chen J,Lu S,Zou Z,Zhou Y,Zhang X

Mon Mar 01 00:00:00 EST 2021

MYH9 is crucial for stem cell-like properties in non-small cell lung cancer by activating mTOR signaling.

Cell death discovery

Chen M,Sun LX,Yu L,Liu J,Sun LC,Yang ZH,Shu X,Ran YL

Mon Oct 11 00:00:00 EDT 2021

Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition.

Frontiers in cell and developmental biology

Landin Malt A,Clancy S,Hwang D,Liu A,Smith C,Smith M,Hatley M,Clemens C,Lu X

Thu Sep 23 00:00:00 EDT 2021

PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin.

OncoTargets and therapy

Wei L,Li P,Luo Y,Zhang M,Yan T,Yang Y,Han Y,Liu S,Wang E

Sun Apr 17 00:00:00 EDT 2022

Wnts regulate planar cell polarity via heterotrimeric G protein and PI3K signaling.

The Journal of cell biology

Landin Malt A,Hogan AK,Smith CD,Madani MS,Lu X

Mon Oct 05 00:00:00 EDT 2020

Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

Journal of cellular biochemistry

Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

Sat Dec 01 00:00:00 EST 2018

Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

Journal of cellular biochemistry

Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

Sat Dec 01 00:00:00 EST 2018

Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

Journal of cellular biochemistry

Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

Sat Dec 01 00:00:00 EST 2018

Characterization of potential TRPP2 regulating proteins in early Xenopus embryos.

Journal of cellular biochemistry

Futel M,Le Bouffant R,Buisson I,Umbhauer M,Riou JF

Sat Dec 01 00:00:00 EST 2018

Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice.

International journal of molecular medicine

Xing F,Yi WJ,Miao F,Su MY,Lei TC

Sun Apr 01 00:00:00 EDT 2018

YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury.

Cell death & disease

Deng F,Peng L,Li Z,Tan G,Liang E,Chen S,Zhao X,Zhi F

Fri Feb 02 00:00:00 EST 2018

YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury.

Cell death & disease

Deng F,Peng L,Li Z,Tan G,Liang E,Chen S,Zhao X,Zhi F

Fri Feb 02 00:00:00 EST 2018

The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.

Development (Cambridge, England)

Rauschenberger V,Bernkopf DB,Krenn S,Jalal K,Heller J,Behrens J,Gentzel M,Schambony A

Thu Jun 15 00:00:00 EDT 2017

The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.

Development (Cambridge, England)

Rauschenberger V,Bernkopf DB,Krenn S,Jalal K,Heller J,Behrens J,Gentzel M,Schambony A

Thu Jun 15 00:00:00 EDT 2017

Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway.

International journal of molecular medicine

Shi ZY,Deng JX,Fu S,Wang L,Wang Q,Liu B,Li YQ,Deng JB

Fri Dec 01 00:00:00 EST 2017

Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway.

International journal of molecular medicine

Shi ZY,Deng JX,Fu S,Wang L,Wang Q,Liu B,Li YQ,Deng JB

Fri Dec 01 00:00:00 EST 2017

Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b.

Scientific reports

Dai J,Wang Z,Xu W,Zhang M,Zhu Z,Zhao X,Zhang D,Nie D,Wang L,Qiao Z

Fri Aug 04 00:00:00 EDT 2017

Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b.

Scientific reports

Dai J,Wang Z,Xu W,Zhang M,Zhu Z,Zhao X,Zhang D,Nie D,Wang L,Qiao Z

Fri Aug 04 00:00:00 EDT 2017

Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b.

Scientific reports

Dai J,Wang Z,Xu W,Zhang M,Zhu Z,Zhao X,Zhang D,Nie D,Wang L,Qiao Z

Fri Aug 04 00:00:00 EDT 2017

Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b.

Scientific reports

Dai J,Wang Z,Xu W,Zhang M,Zhu Z,Zhao X,Zhang D,Nie D,Wang L,Qiao Z

Fri Aug 04 00:00:00 EDT 2017

Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway.

Molecular medicine reports

Chen X,Guo J,Yuan Y,Sun Z,Chen B,Tong X,Zhang L,Shen C,Zou J

Mon May 01 00:00:00 EDT 2017

Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.

Molecular biology of the cell

Gentzel M,Schille C,Rauschenberger V,Schambony A

Sun Mar 01 00:00:00 EST 2015

Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.

Molecular biology of the cell

Gentzel M,Schille C,Rauschenberger V,Schambony A

Sun Mar 01 00:00:00 EST 2015

Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.

Molecular biology of the cell

Gentzel M,Schille C,Rauschenberger V,Schambony A

Sun Mar 01 00:00:00 EST 2015

Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.

Molecular biology of the cell

Gentzel M,Schille C,Rauschenberger V,Schambony A

Sun Mar 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: dishevelled 2; dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2

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Gene Aliases: Dvl-2; DVL2

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UniProt ID: (Human) O14641, (Mouse) Q60838

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Entrez Gene ID: (Human) 1856, (Mouse) 13543, (Rat) 303251

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Function(s)

frizzled binding protein binding protein kinase binding protein domain specific binding protein binding, bridging identical protein binding protein self-association Rac GTPase binding scaffold/adaptor protein

Process(es)

neural tube closure positive regulation of protein phosphorylation outflow tract morphogenesis transcription from RNA polymerase II promoter segment specification heart development Wnt signaling pathway convergent extension involved in neural plate elongation cellular protein localization hippo signaling non-canonical Wnt signaling pathway positive regulation of JUN kinase activity positive regulation of GTPase activity canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity protein oligomerization canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway positive regulation of protein tyrosine kinase activity negative regulation of canonical Wnt signaling pathway cochlea morphogenesis planar cell polarity pathway involved in neural tube closure positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex disassembly heart morphogenesis multicellular organism development segmentation intracellular signal transduction convergent extension involved in organogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DVL2 Polyclonal Antibody

DVL2 Antibody (12037-1-AP) in ICC/IF

Product Details

12037-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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