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Product Details
PA5-27965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 223 and 550 of Human Dishevelled 2
Conjugate
Form
Liquid
Concentration
1.04 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545441
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (80%), Xenopus laevis (83%), Rhesus Monkey (99%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Disheveled DVL2 is a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dishevelled 2 (homologous to Drosophila dsh); dishevelled, dsh homolog 2; Dishevelled-2; DSH homolog 2; Segment polarity protein dishevelled homolog DVL-2
Gene Aliases: DVL2
UniProt ID: (Human) O14641, (Mouse) Q60838
Entrez Gene ID: (Human) 1856, (Mouse) 13543
neural tube closure
positive regulation of protein phosphorylation
outflow tract morphogenesis
transcription from RNA polymerase II promoter
segment specification
heart development
Wnt signaling pathway
convergent extension involved in neural plate elongation
cellular protein localization
hippo signaling
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of GTPase activity
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
protein oligomerization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
positive regulation of protein tyrosine kinase activity
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
beta-catenin destruction complex disassembly
heart morphogenesis
multicellular organism development
segmentation
intracellular signal transduction
convergent extension involved in organogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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