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Immunogen sequence: MSDRKAVIK NADMSEDMQQ DAVDCATQAM EKYNIEKDIA AYIKKEFDKK YNPTWHCIVG RNFGSYVTHE TKHFIYFYLG QVAILLFKSG (1-89 aa encoded by BC010744 )
The directed movement of membrane-bounded organelles is an important process for various cellular functions including membrane transport, secretion, and axonal transport. Cytoplasmic dynein, a ubiquitous minus end-directed microtubule-based motor protein, is believed to be responsible for the retrograde transport of membranous organelles from the synapse to the cell body in fast axonal transport. The cytoplasmic dynein complex is composed of two ~530 kDa heavy chains, and intermediate chains of ~74 kDa and ~53-59 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 8 kDa dynein light chain b; DLC8; DLC8b; Dynein light chain 2, cytoplasmic; Dynein light chain LC8-type 2; dynein light chain-2; dynein, light chain, LC8-type 2; radial spoke 22 homolog
Gene Aliases: 1700064A15Rik; 6720463E02Rik; C87222; DLC2; DLC8; DLC8b; DNCL1B; DYNLL2; RSPH22
UniProt ID: (Human) Q96FJ2, (Rat) Q78P75, (Mouse) Q9D0M5
Entrez Gene ID: (Human) 140735, (Rat) 140734, (Mouse) 68097
Molecular Function:
microtubule or microtubule-binding cytoskeletal protein
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