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Product Details
H00001859-M01
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
7D10
Immunogen
DYRK1A (NP_001387, 674 a.a. approximately 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS
Target Information
DYRK1A is a dual specificity kinase involved in cell proliferation. The gene for DYRK1A is located in the Down syndrome critical region of chromosome 21, and has been implicated in the pathogenesis of this disease. DYRK1A catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual specificity YAK1-related kinase; hMNB; HP86; mnb protein kinase homolog hp86; MNB/DYRK protein kinase; MNBH; MP86; OTTHUMP00000109090; Protein kinase minibrain homolog; serine/threonine kinase MNB; serine/threonine-specific protein kinase
Gene Aliases: 2310043O08Rik; D16Ertd272e; D16Ertd493e; DYRK; DYRK1; DYRK1A; ENSMUSG00000074897; Gm10783; HP86; mmb; MNB; MNBH; Mp86; MRD7
UniProt ID: (Human) Q13627, (Mouse) Q61214
Entrez Gene ID: (Human) 1859, (Mouse) 13548
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
protein self-association
tau protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
regulation of alternative mRNA splicing, via spliceosome
protein phosphorylation
circadian rhythm
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
peptidyl-tyrosine phosphorylation
negative regulation of DNA damage response, signal transduction by p53 class mediator
protein autophosphorylation
negative regulation of mRNA splicing, via spliceosome
positive regulation of protein deacetylation
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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