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Invitrogen
Desmin Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-119736
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human desmin aa 405-470
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913308
Product Specific Information
Positive Control: Human heart tissue, human skeletal muscle tissue, mouse heart tissue, human uterus tissue, mouse skeletal muscle tissue, HepG2,NIH-3T3,Hela
Subcellular Location: Cytoplasm
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CMD1I; Desmin; FLJ12025; FLJ39719; FLJ41013; FLJ41793; intermediate filament protein; MFM1; mutant desmin p.K241E; SCPNK
Gene Aliases: cb290; CSM1; CSM2; DES; desm; LGMD2R; wu:fb59a12; wu:fc11d08; zgc:109859; zgc:154009
UniProt ID: (Human) P17661, (Rat) P48675, (Mouse) P31001
Entrez Gene ID: (Human) 1674, (Rat) 64362, (Mouse) 13346, (Zebrafish) 30148, (Zebrafish) 768287
muscle contraction
locomotory behavior
skeletal muscle organ development
muscle organ development
cytoskeleton organization
regulation of heart contraction
muscle filament sliding
intermediate filament organization
skeletal muscle tissue development
regulation of cardiac muscle contraction by calcium ion signaling
myofibril assembly
sarcomere organization
regulation of cardiac muscle contraction
heart contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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