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Product Details
13876-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Desmocollin 2 Fusion Protein Ag4956 (25-357 aa encoded by BC063291)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LIFASDACK NVTLHVPSKL DAEKLVGRVN LKECFTAANL IHSSDPDFQI LEDGSVYTTN TILLSSEKRS FTILLSNTEN QEKKKIFVFL EHQTKVLKKR HTKEKVLRRA KRRWAPIPCS MLENSLGPFP LFLQQVQSDT AQNYTIYYSI RGPGVDQEPR NLFYVERDTG NLYCTRPVDR EQYESFEIIA FATTPDGYTP ELPLPLIIKI EDENDNYPIF TEETYTFTIF ENCRVGTTVG QVCATDKDEP DTMHTRLKYS IIGQVPPSPT LFSMHPTTGV ITTTSSQLDR ELIDKYQLKI KVQDMDGQYF GLQTTSTCII NIDDVNDHLP TFTR (25-357 aa encoded by BC063291)
Target Information
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ARVC10; ARVD10; Cadherin family member 2; CDHF5; CDHF6; CMD1BB; Desmocollin-2; Desmocollin-3; desmoglein-2; desmoglein-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; Epithelial type 2 desmocollin
Gene Aliases: ARVD11; AW228162; CDHF2; DG2; DGII/III; DSC2; Dsc2a; Dsc2b; DSC3
UniProt ID: (Human) Q02487, (Mouse) P55292
Entrez Gene ID: (Human) 1824, (Mouse) 13506
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
cellular response to starvation
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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