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Invitrogen
Desmoglein 3 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
Desmoglein 3 Antibody (PA5-84316)
Relative expression in different tissues in IHC: Detection of differential expression levels of Desmoglein 3 demonstrates antibody specificity. Immunohistochemical analysis of Desmoglein 3 using anti-Desmoglein 3 Polyclonal Antibody (Product #PA5-84316), shows significant staining of Desmoglein 3 in esophagus and shows minimal or weak staining in stomach tissues. The relative expression levels of Desmoglei... View More
Product Details
PA5-84316
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DSG3. Recombinant protein control fragment (Product #
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Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2791468
Product Specific Information
Immunogen sequence: FRPASKTFTV QKGISSKKLV DYILGTYQAI DEDTNKAASN VKYVMGRNDG GYLMIDSKTA EIKFVKNMNR DSTFIVNKTI TAEVLAIDEY TGKTSTGTVY VRVPDFND
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa pemphigus vulgaris antigen; Cadherin family member 6; Desmoglein-3; DKFZp686P23184; PVA
Gene Aliases: CDHF6; DSG3; PVA
UniProt ID: (Human) P32926
Entrez Gene ID: (Human) 1830
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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