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Invitrogen
Desmoglein 3 Recombinant Rabbit Monoclonal Antibody (ARC1190)
Product Details
MA5-35682
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1190
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 900-999 of human Desmoglein 3 (P32926)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849582
Product Specific Information
Immunogen sequence: TLSGSQGASA LSTSGSVQPA VSIPDPLQHG NYLVTETYSA SGSLVQPSTA GFDPLLTQNV IVTERVICPI SSVPGNLAGP TQLRGSHTML CTEDPCSRLI
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; Cadherin family member 6; Desmoglein-3; DKFZp686P23184; PVA
Gene Aliases: bal; balding; CDHF6; DSG3; PVA
UniProt ID: (Human) P32926, (Mouse) O35902
Entrez Gene ID: (Human) 1830, (Mouse) 13512
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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