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Drosha Antibody (A301-886A-T) in WB
Detection of human Drosha by western blot. Samples: Whole cell lysate (50 µg) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-Drosha antibody A301-886A-M (lot A301-886A-M-2) used for WB at 1:1000. Detection: Chemiluminescence with an exposure time of 10 seconds.
Product Details
A301-886A-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Between 1324 and 1374
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; MGC115770; nuclear RNase III Drosha; OTTHUMP00000220910; OTTHUMP00000220911; OTTHUMP00000220912; OTTHUMP00000220913; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; Ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RNase III
Gene Aliases: DROSHA; ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN
UniProt ID: (Human) Q9NRR4
Entrez Gene ID: (Human) 29102
miRNA metabolic process
positive regulation of gene expression
rRNA catabolic process
production of siRNA involved in RNA interference
gene silencing by RNA
primary miRNA processing
pre-miRNA processing
ribosome biogenesis
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
RNA phosphodiester bond hydrolysis, endonucleolytic
regulation of miRNA metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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