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Dystrophin Antibody (MA5-50847) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Dystrophin in Human Cerebrum Tissue. Samples were incubated in Dystrophin monoclonal antibody (Product # MA5-50847) using a dilution of 30 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining.
Product Details
MA5-50847
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C8
Immunogen
Recombinant Human DMD protein, Ile253-Lys597 (Accession #P11532)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3094005
Target Information
Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apodystrophin-3; apodystrophin-I; DMD; Duchenne muscular dystrophy (DMD); Dystrophin; dystrophin, muscular dystrophy; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592
Gene Aliases: BMD; CMD3B; DMD; DNADMD1; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85
UniProt ID: (Pig) Q5GN48, (Human) P11532
Entrez Gene ID: (Pig) 497636, (Human) 1756, (Rat) 24907
regulation of heart rate
cytoskeleton organization
muscle organ development
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of skeletal muscle contraction
muscle attachment
muscle filament sliding
negative regulation of peptidyl-serine phosphorylation
cellular protein localization
response to muscle stretch
peptide biosynthetic process
cellular protein complex assembly
muscle cell cellular homeostasis
muscle fiber development
cardiac muscle contraction
regulation of ryanodine-sensitive calcium-release channel activity
cardiac muscle cell action potential
regulation of voltage-gated calcium channel activity
negative regulation of peptidyl-cysteine S-nitrosylation
positive regulation of sodium ion transmembrane transporter activity
positive regulation of cell-matrix adhesion
regulation of transcription, DNA-templated
skeletal muscle tissue development
aging
establishment of blood-nerve barrier
regulation of gene expression
positive regulation of neuron projection development
myotube cell development
olfactory nerve structural organization
cell differentiation
regulation of membrane potential
muscle cell differentiation
neurotransmitter receptor metabolic process
positive regulation of neuron differentiation
neuron projection morphogenesis
nucleus localization
establishment of glial blood-brain barrier
negative regulation of ERK1 and ERK2 cascade
regulation of cellular response to growth factor stimulus
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