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Product Details
PA5-142947
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-TKGLFQTPYRSARN.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933589
Product Specific Information
Additional Information: Reported isoforms represent identical protein: NP_524437.2; NP_732646.1; NP_732647.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG6376-PA; CG6376-PB; CG6376-PC; CG6376-PD; CG6376-PE; CG6376-PF; dE2F; E2-promoter binding factor; E2F transcription factor; E2f1-PA; E2f1-PB; E2f1-PC; E2f1-PD; E2f1-PE; E2f1-PF; LD35741p; Transcription factor E2f1
Gene Aliases: CG6376; dE2F; dE2F1; def21; DmE2F-1; Dmel\CG6376; Dmel_CG6376; Dp; drosE2F1; DRTF1/E2F; E(Sev-CycE)3A; E(var)3-93E; E(var)3-95E; E(var)93E; E2F; E2F-1; E2F1; Evar(3)164; l(3)07172; l(3)j3B1; l(3)j3C2; l(3)rM729
UniProt ID: (Fruit fly) Q27368
Entrez Gene ID: (Fruit fly) 42550
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
protein dimerization activity
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
eggshell chorion gene amplification
ventral cord development
regulation of gene expression
positive regulation of gene expression
positive regulation of DNA endoreduplication
larval lymph gland hemopoiesis
regulation of hemocyte proliferation
DNA endoreduplication
positive regulation of apoptotic process
positive regulation of nurse cell apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
regulation of execution phase of apoptosis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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