Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: EVSWREFMKQ HYLSPSREFR EYKCDVLMRE NEALKDKSSH MFIYISWYKI EHICTSDNWM DRFRNAYVWV QNPLKVLKCH QENSKNSYTE SRSFNYIEFH CSMDGYVDSI EDLKMVEPIG N
Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 58%.
Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epididymal secretory protein E3 beta; Epididymal secretory protein E3-beta; family with sequence similarity 12, member B (epididymal); HE3-beta; human epididymis-specific 3 beta; Human epididymis-specific protein 3-beta; ribonuclease A M2
Gene Aliases: EDDM3B; EP3B; FAM12B; HE3-BETA; HE3B; RAM2; UNQ6412/PRO21187
UniProt ID: (Human) P56851
Entrez Gene ID: (Human) 64184
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