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Immunogen sequence: YLYLLFADKE DIIFDIEDYI FTTEAHLLPL WLSTTNQSIS KKNTTSEYTE LDDSNFDWTC PNTQILFPND PLYAQSIREP L
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 98%.
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-1,2-mannosidase EDEM3; ER degradation enhancer, mannosidase alpha-like 3; ER degradation-enhancing -mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like 3; ER degradation-enhancing alpha-mannosidase-like protein 3
Gene Aliases: C1orf22; EDEM3
UniProt ID: (Human) Q9BZQ6
Entrez Gene ID: (Human) 80267
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