Product References
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.
Communications biology
Sato W,Watanabe-Takahashi M,Murata T,Utsunomiya-Tate N,Motoyama J,Anzai M,Ishihara S,Nishioka N,Uchiyama H,Togashi J,Nishihara S,Kawasaki K,Saito T,Saido TC,Funamoto S,Nishikawa K
PA1-063A was used in Immunocytochemistry to identify a tetravalent peptide, LME-tet, which binds APP and Aβ via multivalent interactions.
Sat Apr 08 00:00:00 EDT 2023
Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH.
PLoS pathogens
Distel JS,Di Venanzio G,Mackel JJ,Rosen DA,Feldman MF
PA1-063A was used in Immunocytochemistry-immunofluorescence to demonstrate that the modern A. baumannii clinical isolate 398, but not the lab strain 19606, can infect alveolar macrophages and produce Acinetobacter Containing Vacuoles (ACV) in vivo in a murine pneumonia model.
Thu Jun 01 00:00:00 EDT 2023
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.
The Journal of cell biology
Hancock-Cerutti W,Wu Z,Xu P,Yadavalli N,Leonzino M,Tharkeshwar AK,Ferguson SM,Shadel GS,De Camilli P
PA1-063A was used in Western Blotting to suggest a link between ER-lysosome lipid transfer and innate immune activation in a model human cell line and place VPS13C in pathways relevant to PD pathogenesis.
Mon Jul 04 00:00:00 EDT 2022
Clostridium botulinum C3 Toxin for Selective Delivery of Cargo into Dendritic Cells and Macrophages.
Toxins
Fellermann M,Stemmer M,Noschka R,Wondany F,Fischer S,Michaelis J,Stenger S,Barth H
PA1-063A was used in Western Blotting to illustrate that non-toxic C3botE174Q is a promising candidate for the cell-type-selective delivery of small molecules, peptides, and proteins into the cytosol of macrophages and DCs.
Tue Oct 18 00:00:00 EDT 2022
Clostridium botulinum C3 Toxin for Selective Delivery of Cargo into Dendritic Cells and Macrophages.
Toxins
Fellermann M,Stemmer M,Noschka R,Wondany F,Fischer S,Michaelis J,Stenger S,Barth H
PA1-063A was used in Western Blotting to illustrate that non-toxic C3botE174Q is a promising candidate for the cell-type-selective delivery of small molecules, peptides, and proteins into the cytosol of macrophages and DCs.
Tue Oct 18 00:00:00 EDT 2022
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21).
Scientific reports
Cejas RB,Tamaño-Blanco M,Blanco JG
PA1-063A was used in Immunocytochemistry to analyse the intracellular traffic of IgG mediated by the human neonatal Fc receptor (FcRn) in fibroblast cell lines with trisomy 21.
Wed May 26 00:00:00 EDT 2021
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21).
Scientific reports
Cejas RB,Tamaño-Blanco M,Blanco JG
PA1-063A was used in Immunocytochemistry to analyse the intracellular traffic of IgG mediated by the human neonatal Fc receptor (FcRn) in fibroblast cell lines with trisomy 21.
Wed May 26 00:00:00 EDT 2021
Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence.
Communications biology
Pan JX,Sun D,Lee D,Xiong L,Ren X,Guo HH,Yao LL,Lu Y,Jung C,Xiong WC
PA1-063A was used in Immunocytochemistry to show that TgAPPsweOCN mice also exhibit Alzheimer's disease-relevant brain pathologies and behavior phenotypes.
Thu Nov 25 00:00:00 EST 2021
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Cell reports. Medicine
Lu SC,Chen M,Atangan L,Killion EA,Komorowski R,Cheng Y,Netirojjanakul C,Falsey JR,Stolina M,Dwyer D,Hale C,Stanislaus S,Hager T,Thomas VA,Harrold JM,Lloyd DJ,Véniant MM
PA1-063A was used in Immunocytochemistry to conclude that GIPR-Ab/GLP-1 molecules promote BW loss, and they may be used for treating obesity.© 2021 Amgen Inc.
Tue May 18 00:00:00 EDT 2021
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys.
Cell reports. Medicine
Lu SC,Chen M,Atangan L,Killion EA,Komorowski R,Cheng Y,Netirojjanakul C,Falsey JR,Stolina M,Dwyer D,Hale C,Stanislaus S,Hager T,Thomas VA,Harrold JM,Lloyd DJ,Véniant MM
PA1-063A was used in Immunocytochemistry to conclude that GIPR-Ab/GLP-1 molecules promote BW loss, and they may be used for treating obesity.© 2021 Amgen Inc.
Tue May 18 00:00:00 EDT 2021
A conserved dendritic-cell regulatory program limits antitumour immunity.
Nature
Maier B,Leader AM,Chen ST,Tung N,Chang C,LeBerichel J,Chudnovskiy A,Maskey S,Walker L,Finnigan JP,Kirkling ME,Reizis B,Ghosh S,D'Amore NR,Bhardwaj N,Rothlin CV,Wolf A,Flores R,Marron T,Rahman AH,Kenigsberg E,Brown BD,Merad M
PA1-063A was used in Immunocytochemistry to study a regulatory module associated with tumour-antigen uptake that reduces DC1 functionality in human and mouse cancers.
Wed Apr 01 00:00:00 EDT 2020
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
The EMBO journal
Weinert S,Gimber N,Deuschel D,Stuhlmann T,Puchkov D,Farsi Z,Ludwig CF,Novarino G,López-Cayuqueo KI,Planells-Cases R,Jentsch TJ
PA1-063A was used in Immunocytochemistry-immunoflourescence to generate Clcn3unc/unc mice in which ClC-3 is converted into a Cl- channel.
Mon May 04 00:00:00 EDT 2020
Photoactivation of sulfonated polyplexes enables localized gene silencing by DsiRNA in breast cancer cells.
Nanomedicine : nanotechnology, biology, and medicine
Puri A,Viard M,Zakrevsky P,Zampino S,Chen A,Isemann C,Alvi S,Clogston J,Chitgupi U,Lovell JF,Shapiro BA
PA1-063A was used in Immunocytochemistry to develop novel polyplexes for controlled intracellular delivery of dicer substrate siRNA, using a light activation approach.
Mon Jun 01 00:00:00 EDT 2020
Coxiella burnetii Type 4B Secretion System-dependent manipulation of endolysosomal maturation is required for bacterial growth.
PLoS pathogens
Samanta D,Clemente TM,Schuler BE,Gilk SD
Published figure using EEA1 polyclonal antibody (Product # PA1-063A) in Immunofluorescence
Sun Dec 01 00:00:00 EST 2019
Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.
Journal of food and drug analysis
Yang MH,Chen SC,Lin YF,Lee YC,Huang MY,Chen KC,Wu HY,Lin PC,Gozes I,Tyan YC
PA1-063A was used in Immunocytochemistry-immunoflourescence to identify protein biomarkers associated with aluminum ions toxicity in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP.
Mon Apr 01 00:00:00 EDT 2019
Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.
Journal of food and drug analysis
Yang MH,Chen SC,Lin YF,Lee YC,Huang MY,Chen KC,Wu HY,Lin PC,Gozes I,Tyan YC
PA1-063A was used in Immunocytochemistry-immunoflourescence to identify protein biomarkers associated with aluminum ions toxicity in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP.
Mon Apr 01 00:00:00 EDT 2019
The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells.
The journal of physiological sciences : JPS
Aung KT,Yoshioka K,Aki S,Ishimaru K,Takuwa N,Takuwa Y
PA1-063A was used in Immunohistochemistry to investigate which Phosphoinositide 3-kinases isoforms are involved in specific mechanisms of pinocytosis.
Fri Mar 01 00:00:00 EST 2019
Human plasma C3 is essential for the development of memory B, but not T, lymphocytes.
The Journal of allergy and clinical immunology
Jiménez-Reinoso A,Marin AV,Subias M,López-Lera A,Román-Ortiz E,Payne K,Ma CS,Arbore G,Kolev M,Freeley SJ,Kemper C,Tangye SG,Fernández-Malavé E,Rodríguez de Córdoba S,López-Trascasa M,Regueiro JR
PA1-063A was used in Immunocytochemistry-Immunofluorescence to study whether reduced plasma C3 levels could affect lymphocyte differentiation.
Thu Mar 01 00:00:00 EST 2018
Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate.
PloS one
Saxena M,Delgado Y,Sharma RK,Sharma S,Guzmán SLPL,Tinoco AD,Griebenow K
PA1-063A was used in Immunocytochemistry to develop a conjugate of cytochrome c with transferrin in order to actively target lung cancer cells.
Wed Jul 18 00:00:00 EDT 2018
Inducing cell death in vitro in cancer cells by targeted delivery of cytochrome c via a transferrin conjugate.
PloS one
Saxena M,Delgado Y,Sharma RK,Sharma S,Guzmán SLPL,Tinoco AD,Griebenow K
PA1-063A was used in Immunocytochemistry to develop a conjugate of cytochrome c with transferrin in order to actively target lung cancer cells.
Wed Jul 18 00:00:00 EDT 2018
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity.
eLife
Farsi Z,Gowrisankaran S,Krunic M,Rammner B,Woehler A,Lafer EM,Mim C,Jahn R,Milosevic I
PA1-063A was used in Western Blotting to propose a model in which the formation of the coat surrounds the vATPase and blocks its activity. Such inhibition is likely fundamental for the proper timing of SV refilling.
Fri Apr 13 00:00:00 EDT 2018
Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.
Cell death discovery
Duclos CM,Champagne A,Carrier JC,Saucier C,Lavoie CL,Denault JB
Published figure using EEA1 polyclonal antibody (Product # PA1-063A) in Immunofluorescence
Wed Sep 30 00:00:00 EDT 2020
GM130 gain-of-function induces cell pathology in a model of lysosomal storage disease.
Human molecular genetics
Roy E,Bruyère J,Flamant P,Bigou S,Ausseil J,Vitry S,Heard JM
PA1-063A was used in immunocytochemistry to investigate the role of GM130 during lysosomal biogenesis
Sun Apr 01 00:00:00 EDT 2012
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Bruscia EM,Zhang PX,Satoh A,Caputo C,Medzhitov R,Shenoy A,Egan ME,Krause DS
PA1-063A was used in western blot to study the mechanism for the elevated inflammatory response in cystic fibrosis
Wed Jun 15 00:00:00 EDT 2011
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Bruscia EM,Zhang PX,Satoh A,Caputo C,Medzhitov R,Shenoy A,Egan ME,Krause DS
PA1-063A was used in western blot to study the mechanism for the elevated inflammatory response in cystic fibrosis
Wed Jun 15 00:00:00 EDT 2011
Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine.
American journal of physiology. Gastrointestinal and liver physiology
Jakab RL,Collaco AM,Ameen NA
PA1-063A was used in immunohistochemistry to investigate the distribution patterns of four ion transporters along the crypt-villus axis in the intestine
Sat Jan 01 00:00:00 EST 2011
The phospholipase A₂ enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking.
Molecular biology of the cell
Bechler ME,Doody AM,Ha KD,Judson BL,Chen I,Brown WJ
PA1-063A was used in western blot to study the role of platelet-activating factor acetylhydrolase Ib (PAFAH) in endosomal export
Fri Jul 01 00:00:00 EDT 2011
UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.
PloS one
Itoh H,Tatematsu M,Watanabe A,Iwano K,Funami K,Seya T,Matsumoto M
Published figure using EEA1 polyclonal antibody (Product # PA1-063A) in Immunofluorescence
Fri Jul 20 00:00:00 EDT 2012
UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.
PloS one
Itoh H,Tatematsu M,Watanabe A,Iwano K,Funami K,Seya T,Matsumoto M
Published figure using EEA1 polyclonal antibody (Product # PA1-063A) in Immunofluorescence
Fri Jul 20 00:00:00 EDT 2012
Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.
The Journal of biological chemistry
Béliveau F,Brulé C,Désilets A,Zimmerman B,Laporte SA,Lavoie CL,Leduc R
PA1-063A was used in immunocytochemistry to investigate the mechanism for TMPRSS6 function in iron homeostasis
Fri Aug 19 00:00:00 EDT 2011
Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures.
American journal of physiology. Lung cellular and molecular physiology
Cholon DM,O'Neal WK,Randell SH,Riordan JR,Gentzsch M
PA1-063A was used in immunocytochemistry to investigate the trafficking and stability of CFTR in primary human airway epithelial cells
Mon Mar 01 00:00:00 EST 2010
Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells.
Molecular biology of the cell
Govindarajan R,Chakraborty S,Johnson KE,Falk MM,Wheelock MJ,Johnson KR,Mehta PP
PA1-063A was used in immunocytochemistry to investigate the regulation of the Cx43 assembly by E-cadherin and N-cadherin
Wed Dec 01 00:00:00 EST 2010
Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability.
Acta biochimica et biophysica Sinica
Yao Y,Wang G,Li Z,Yan B,Guo Y,Jiang X,Xi Z
PA1-063A was used in western blot to study the localization and function of EGFR in mitochondria
Mon Nov 01 00:00:00 EDT 2010
E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells.
The Journal of biological chemistry
Chakraborty S,Mitra S,Falk MM,Caplan SH,Wheelock MJ,Johnson KR,Mehta PP
PA1-063A was used in immunocytochemistry to investigate the effect of E-cadherin on gap junction formation in cancer cells
Fri Apr 02 00:00:00 EDT 2010
Endocytosis in cultured neurons is altered by chronic alcohol exposure.
Toxicological sciences : an official journal of the Society of Toxicology
Marín MP,Esteban-Pretel G,Ponsoda X,Romero AM,Ballestín R,López C,Megías L,Timoneda J,Molowny A,Canales JJ,Renau-Piqueras J
PA1-063A was used in western blot to investigate the influence of chronic alcohol consumption on neuronal endocytosis
Sat May 01 00:00:00 EDT 2010
Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.
The Journal of biological chemistry
Duit S,Mayer H,Blake SM,Schneider WJ,Nimpf J
PA1-063A was used in immunocytochemistry to investigate the different roles of ApoER2 and very low density lipoprotein receptor in Reelin signaling and their mechanism
Fri Feb 12 00:00:00 EST 2010
HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.
The Journal of biological chemistry
Yi L,Rosales T,Rose JJ,Chowdhury B,Knutson JR,Venkatesan S
PA1-063A was used in immunocytochemistry to study the mechanisms of HLA-1 down regulation by HIV-1 Nef.
Fri Oct 01 00:00:00 EDT 2010
Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms.
American journal of physiology. Lung cellular and molecular physiology
Mulugeta S,Maguire JA,Newitt JL,Russo SJ,Kotorashvili A,Beers MF
PA1-063A was used in immunocytochemistry to study the mechanism that misfolded BRICHOS SP-C mutant proteins could induce apoptosis
Sat Sep 01 00:00:00 EDT 2007
Urocortin trafficking in cerebral microvessel endothelial cells.
Journal of molecular neuroscience : MN
Tu H,Kastin AJ,Bjorbaek C,Pan W
PA1-063A was used in immunocytochemistry to investigate the mechanism of urocortin endocytosis in cerebral microvessel endothelial cells
Mon Feb 04 00:00:00 EST 2008
