Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: MATDELATKL SRRLQMEGEG GGETPEQPGL NGAAAAAAGA PDEAAEALGS ADCELSAKLL RRADLNQGIG EPQSPSRR; Positive Samples: Mouse lung; Cellular Location: Membrane raft
EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.
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Protein Aliases: EF-hand domain-containing protein D2; MGC4342; RP3-467K16.3; swiprosin 1; swiprosin-1
Gene Aliases: 2600015J22Rik; AA408606; D4Wsu27e
Entrez Gene ID: (Mouse) 27984
Molecular Function:
calmodulin-related
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