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EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
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Protein Aliases: eIF2 alpha; eIF2 alpha subunit; translation initiation factor subunit
Gene Aliases: eif2; eif2s1; fb19d01; wu:fb19d01
Entrez Gene ID: (Zebrafish) 321564
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