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Product Details
11182-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EIF4EBP2 Fusion Protein Ag1670 (1-120 aa encoded by BC050633)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSSAGSGH QPSQSRAIPT RTVAISDAAQ LPHDYCTTPG GTLFSTTPGG TRIIYDRKFL LDRRNSPMAQ TPPCHLPNIP GVTSPGTLIE DSKVEVNNLN NLNNHDRKHA VGDDAQFEMD I (1-120 aa encoded by BC050633)
Target Information
PHAS-II (eIF4E-binding protein II) is involved in translation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation initiation. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II. Thus, PHAS proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4E-BP2; eIF4E-binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; PHAS-II; Phosphorylated heat- and acid-stable protein regulated by insulin 2; phosphorylated, heat and acid stable regulated by insulin protein II
Gene Aliases: 2810011I19Rik; 4E-BP2; 4EBP2; AA792569; BC010348; EIF4EBP2; PHAS-II; PHASII
UniProt ID: (Human) Q13542, (Mouse) P70445
Entrez Gene ID: (Human) 1979, (Mouse) 13688
translation
memory
insulin receptor signaling pathway
cAMP-mediated signaling
TOR signaling
social behavior
negative regulation of translational initiation
regulation of synaptic plasticity
modulation of synaptic transmission
regulation of translation
regulation of translational initiation
negative regulation of translation
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