Proteintech

EIF4G1 Polyclonal Antibody

EIF4G1 Antibody in Immunocytochemistry (ICC/IF)

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EIF4G1 Antibody (15704-1-AP) in ICC/IF

Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 15704-1-AP (EIF4G1 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

EIF4G1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EIF4G1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15704-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EIF4G1 Fusion Protein Ag8342 (296-645 aa encoded by BC007788)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IEEYLHLND MKEAVQCVQE LASPSLLFIF VRHGVESTLE RSAIAREHMG QLLHQLLCAG HLSTAQYYQG LYEILELAED MEIDIPHVWL YLAELVTPIL QEGGVPMGEL FREITKPLRP LGKAASLLLE ILGLLCKSMG PKKVGTLWRE AGLSWKEFLP EGQDIGAFVA EQKVEYTLGE ESEAPGQRAL PSEELNRQLE KLLKEGSSNQ RVFDWIEANL SEQQIVSNTL VRALMTAVCY SAIIFETPLR VDVAVLKARA KLLQKYLCDE QKELQALYAL QALVVTLEQP PNLLRMFFDA LYDEDVVKED AFYSWESSKD PAEQQGKGVA LKSVTAFFKW LREAEEESDH N (296-645 aa encoded by BC007788)

Target Information

The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LINC02870 facilitates SNAIL translation to promote hepatocellular carcinoma progression.

Molecular and cellular biochemistry

Guo M,Zhuang H,Huang J,Shao X,Bai N,Li M,Niu M,Wei W,Sun L,Li Y,Qiang Z

Fri Sep 01 00:00:00 EDT 2023

CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Huang R,Yamamoto T,Nakata E,Ozaki T,Kurozumi K,Wei F,Tomizawa K,Fujimura A

Sat Apr 01 00:00:00 EDT 2023

5'-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity.

International journal of biological macromolecules

Chen F,Song C,Meng F,Zhu Y,Chen X,Fang X,Ma D,Wang Y,Zhang C

Tue Jan 31 00:00:00 EST 2023

5'-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity.

International journal of biological macromolecules

Chen F,Song C,Meng F,Zhu Y,Chen X,Fang X,Ma D,Wang Y,Zhang C

Tue Jan 31 00:00:00 EST 2023

Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation.

Journal of extracellular vesicles

You B,Pan S,Gu M,Zhang K,Xia T,Zhang S,Chen W,Xie H,Fan Y,Yao H,Cheng T,Zhang P,Liu D,You Y

Sun May 01 00:00:00 EDT 2022

EIF4G1 Is a Potential Prognostic Biomarker of Breast Cancer.

Biomolecules

Li K,Tan G,Zhang X,Lu W,Ren J,Si Y,Adu-Gyamfi EA,Li F,Wang Y,Xie B,Wang M

Sat Nov 26 00:00:00 EST 2022

Construction and validation of a prognostic risk model for breast cancer based on protein expression.

BMC medical genomics

Huang B,Zhang X,Cao Q,Chen J,Lin C,Xiang T,Zeng P

Mon Jul 04 00:00:00 EDT 2022

Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo.

Frontiers in endocrinology

Jo S,Pritchard S,Wong A,Avula N,Essawy A,Hanover J,Alejandro EU

Mon Nov 21 00:00:00 EST 2022

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.

Cell reports

George J,Li Y,Kadamberi IP,Parashar D,Tsaih SW,Gupta P,Geethadevi A,Chen C,Ghosh C,Sun Y,Mittal S,Ramchandran R,Rui H,Lopez-Berestein G,Rodriguez-Aguayo C,Leone G,Rader JS,Sood AK,Dey M,Pradeep S,Chaluvally-Raghavan P

Tue Nov 02 00:00:00 EDT 2021

Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic β-Cell Function.

Diabetes

Jo S,Lockridge A,Mohan R,Esch N,Schlichting R,Panigrahy N,Essawy A,Gustafson E,Alejandro EU

Fri Jan 01 00:00:00 EST 2021

Translational Factor eIF4G1 Regulates Glucose Homeostasis and Pancreatic β-Cell Function.

Diabetes

Jo S,Lockridge A,Mohan R,Esch N,Schlichting R,Panigrahy N,Essawy A,Gustafson E,Alejandro EU

Fri Jan 01 00:00:00 EST 2021

ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms.

Journal of cell science

Corbet GA,Burke JM,Parker R

Wed Sep 01 00:00:00 EDT 2021

Inhibition of Antiviral Innate Immunity by Foot-and-Mouth Disease Virus L^pro through Interaction with the N-Terminal Domain of Swine RNase L.

Journal of virology

Sui C,Jiang D,Wu X,Liu S,Li F,Pan L,Cong X,Li J,Yoo D,Rock DL,Miller LC,Lee C,Du Y,Qi J

Mon Jul 12 00:00:00 EDT 2021

The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.

Molecular cell

Sun L,Wang W,Han C,Huang W,Sun Y,Fang K,Zeng Z,Yang Q,Pan Q,Chen T,Luo X,Chen Y

Thu Nov 04 00:00:00 EDT 2021

ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.

Neurochemical research

Lee DY,Jeon GS,Sung JJ

Tue Dec 01 00:00:00 EST 2020

ALS-Linked Mutant SOD1 Associates with TIA-1 and Alters Stress Granule Dynamics.

Neurochemical research

Lee DY,Jeon GS,Sung JJ

Tue Dec 01 00:00:00 EST 2020

EIF4G1 is a novel candidate gene associated with severe asthenozoospermia.

Molecular genetics & genomic medicine

Sha Y,Liu W,Huang X,Li Y,Ji Z,Mei L,Lin S,Kong S,Lu J,Kong L,Zhu X,Lu Z,Ding L

Thu Aug 01 00:00:00 EDT 2019

EIF4G1 is a novel candidate gene associated with severe asthenozoospermia.

Molecular genetics & genomic medicine

Sha Y,Liu W,Huang X,Li Y,Ji Z,Mei L,Lin S,Kong S,Lu J,Kong L,Zhu X,Lu Z,Ding L

Thu Aug 01 00:00:00 EDT 2019

Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation.

Proceedings of the National Academy of Sciences of the United States of America

Avanzino BC,Fuchs G,Fraser CS

Tue Sep 05 00:00:00 EDT 2017

Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation.

Proceedings of the National Academy of Sciences of the United States of America

Avanzino BC,Fuchs G,Fraser CS

Tue Sep 05 00:00:00 EDT 2017

Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells.

Journal of virological methods

Wehbe M,Huguenin A,Leveque N,Semler BL,Hamze M,Andreoletti L,Bouin A

Fri Apr 01 00:00:00 EDT 2016

Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells.

Journal of virological methods

Wehbe M,Huguenin A,Leveque N,Semler BL,Hamze M,Andreoletti L,Bouin A

Fri Apr 01 00:00:00 EDT 2016

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.

PLoS genetics

Hu S,Li J,Xu F,Mei S,Le Duff Y,Yin L,Pang X,Cen S,Jin Q,Liang C,Guo F

Wed Jul 01 00:00:00 EDT 2015

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.

PLoS genetics

Hu S,Li J,Xu F,Mei S,Le Duff Y,Yin L,Pang X,Cen S,Jin Q,Liang C,Guo F

Wed Jul 01 00:00:00 EDT 2015

Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.

Virology journal

Wu S,Wang Y,Lin L,Si X,Wang T,Zhong X,Tong L,Luan Y,Chen Y,Li X,Zhang F,Zhao W,Zhong Z

Thu Nov 20 00:00:00 EST 2014

Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections.

Virology journal

Wu S,Wang Y,Lin L,Si X,Wang T,Zhong X,Tong L,Luan Y,Chen Y,Li X,Zhang F,Zhao W,Zhong Z

Thu Nov 20 00:00:00 EST 2014

Bioinformatics

Protein Aliases: DKFZp686A1451; eIF-4-gamma 1; EIF4-gamma; eucaryotic translation initiation factor 4G; Eukaryotic translation initiation factor 4 gamma 1; eukaryotic translation initiation factor 4 gamma, 1; OTTHUMP00000210577; OTTHUMP00000210586; OTTHUMP00000210587; OTTHUMP00000210588; OTTHUMP00000210595; OTTHUMP00000210602; OTTHUMP00000210603; p220

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Gene Aliases: EIF-4G1; EIF4F; EIF4G; EIF4G1; EIF4GI; P220; PARK18

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UniProt ID: (Human) Q04637

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Entrez Gene ID: (Human) 1981

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Function(s)

translation initiation factor activity protein binding translation factor activity, RNA binding eukaryotic initiation factor 4E binding poly(A) RNA binding cadherin binding involved in cell-cell adhesion translation factor translation initiation factor translational protein

Process(es)

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening behavioral fear response translational initiation regulation of translational initiation viral process regulation of mRNA stability positive regulation of neuron differentiation cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EIF4G1 Polyclonal Antibody

EIF4G1 Antibody (15704-1-AP) in ICC/IF

Product Details

15704-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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