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KLF1 is a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant Inblood phenotype.
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Protein Aliases: erythroid krueppel-like transcription factor; erythroid transcription factor; Krueppel-like factor 1; neonatal anemia
Gene Aliases: Eklf; Nan
Entrez Gene ID: (Mouse) 16596
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