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Antibody detects endogenous levels of total ENC1.
The ectoderm-neural cortex-1 (ENC-1) protein is an early and highly specific marker of neural induction in vertebrates. It is a kelch family related protein that functions as an actin-binding protein and has been suggested to be involved in the organization of the actin cytoskeleton during neural fate specification and development of the nervous system. ENC-1 has also been shown to be required for adipocyte differentiation when cytoskeletal reorganization and cell shape change from fibroblastic preadipocytes to spherical adipocytes occur.
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Protein Aliases: Ectoderm-neural cortex protein 1; ectodermal-neural cortex 1 (with BTB domain); ectodermal-neural cortex 1 (with BTB-like domain); ENC-1; FLJ39259; kelch-like 35; kelch-like 37; kelch-like family member 37; Kelch-like protein 37; Nuclear matrix protein NRP/B; nuclear restrict protein in brain; nuclear restricted protein, BTB domain-like (brain); p53-induced gene 10 protein; tumor protein p53 inducible protein 10
Gene Aliases: CCL28; ENC-1; ENC1; KLHL35; KLHL37; NRPB; PIG10; TP53I10
UniProt ID: (Human) O14682, (Mouse) O35709
Entrez Gene ID: (Human) 8507, (Mouse) 13803, (Rat) 294674
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