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Product Details
PA5-77967
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Eps15. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.83 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 0.1M glycine, 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2735766
Product Specific Information
Positive Control: Raji, K562, BCL-1
Predicted Reactivity: Chicken (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
EPS15 is a ubiquitously expressed protein that is involved in cell growth regulation and may be involved in the regulation of mitogenic signals and control of cell proliferation. Phosphorylation of EPS15 on Tyrosine 849 upon DNA damage is involved in the internalization of EGFR. A chromosomal aberration involving EPS15 is also found in acute leukemias, resulting in a rogue activator protein.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AF-1p protein; ALL1 fused gene from chromosome 1; epidermal growth factor pathway substrate 15; Epidermal growth factor receptor substrate 15; Protein AF-1p; Protein Eps15
Gene Aliases: 2410112D09Rik; AF-1P; AF1P; EPS15; MLLT5
UniProt ID: (Human) P42566, (Mouse) P42567
Entrez Gene ID: (Human) 2060, (Mouse) 13858
Golgi to endosome transport
epidermal growth factor receptor signaling pathway
cell proliferation
protein transport
vesicle organization
receptor-mediated endocytosis of virus by host cell
endocytic recycling
negative regulation of epidermal growth factor receptor signaling pathway
viral entry into host cell
clathrin coat assembly
cell-cell adhesion
positive regulation of receptor recycling
transport
endocytosis
regulation of cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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