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Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: epidermal growth factor receptor pathway substrate 15-like 1; Epidermal growth factor receptor substrate 15-like 1; epidermal growth factor receptor substrate EPS15R; Eps15-related protein; Eps15R
Gene Aliases: EPS15L1; EPS15R
UniProt ID: (Human) Q9UBC2
Entrez Gene ID: (Human) 58513
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