OriGene

ERBB2 Monoclonal Antibody (UMAB36), UltraMAB™

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

4 References
View all (273) Her-2 (ErbB2) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

UM500036

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-

Immunocytochemistry (ICC/IF)

1:100
-

ChIP assay (ChIP)

Assay-Dependent
-

Miscellaneous PubMed (Misc)

-
View 4 publications 4 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

UMAB36

Immunogen

Human recombinant protein fragment corresponding to amino acids 676-1255 of human ERBB2 produced in HEK293T cell.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-erbB2; c-neu; CD340; Erbb-2; ERBB2; HER-2; HER-2/neu; HER2; Kiaa3023; mKIAA3023; MLN 19; MLN19; NEU; NGL; TKR1

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UniProt ID: (Human) P04626, (Mouse) P70424

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Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

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Function(s)
RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding growth factor binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity nucleotide binding glycoprotein binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding Hsp90 protein binding DNA binding transmembrane signal receptor
Process(es)
MAPK cascade positive regulation of protein phosphorylation transcription, DNA-templated protein phosphorylation signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation positive regulation of cell growth regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus ERBB2 signaling pathway wound healing myelination positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of translation regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase III promoter protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling oligodendrocyte differentiation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of protein targeting to membrane regulation of cell motility regulation of transcription, DNA-templated nervous system development positive regulation of cell proliferation glial cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade estrous cycle positive regulation of Ras protein signal transduction sympathetic nervous system development response to axon injury liver development central nervous system development skeletal muscle tissue development signal transduction by protein phosphorylation response to progesterone regulation of cell proliferation response to drug tongue development regulation of cell differentiation mammary gland involution
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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