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Product Details
TA504405
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5A2
Immunogen
Full length human recombinant protein of human ERCC1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.64 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA excision repair protein ERCC-1; excision repair cross-complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
Gene Aliases: COFS4; ERCC1; RAD10; UV20
UniProt ID: (Human) P07992
Entrez Gene ID: (Human) 2067
pyrimidine dimer repair by nucleotide-excision repair
replicative cell aging
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
double-strand break repair
DNA recombination
mitotic recombination
syncytium formation
response to oxidative stress
spermatogenesis
response to nutrient
cell proliferation
male gonad development
UV protection
response to sucrose
response to X-ray
multicellular organism aging
negative regulation of telomere maintenance
nucleotide-excision repair, DNA incision
post-embryonic hemopoiesis
multicellular organism growth
interstrand cross-link repair
isotype switching
oogenesis
embryonic organ development
global genome nucleotide-excision repair
t-circle formation
positive regulation of t-circle formation
Performance Guarantee
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