Invitrogen

ERK1/ERK2 Monoclonal Antibody (ERK-7D8)

Advanced Verification

This Antibody was verified by Independent antibody to ensure that the antibody binds to the antigen stated.

18 Published Figures

50 References

View all (90) ERK1/2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

ERK1/ERK2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 24

ERK1/ERK2 Antibody (13-6200) in ICC/IF

Immunofluorescent analysis of ERK1 + ERK2 Antibody (ERK-7D8) was done on 70% confluent log phase U87-MG cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with ERK1 + ERK2 Antibody (ERK-7D8) (Product # 13-6200) at 1:250 dilution in1% BSA and incubated for 3 ... View More

ERK1/ERK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ERK1/ERK2 Antibody in Immunohistochemistry (IHC)

ERK1/ERK2 Antibody in Immunoprecipitation (IP)

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Product Details

13-6200

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

View 40 publications 40 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

Immunocytochemistry (ICC/IF)

1 µg/mL

View 3 publications 3 publications

ELISA (ELISA)

0.1-1 mg/mL

Immunoprecipitation (IP)

2-5 µg

View 1 publication 1 publication

Gel Shift (GS)

Assay-dependent

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Hamster, Human, Mouse, Rat, Xenopus

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

ERK-7D8

Immunogen

Synthetic peptide (aa 324-345) corresponding to a segment near the C-terminus of rat ERK1

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533024

Product Specific Information

This antibody reacts strongly with both ERK1 and ERK2. Reactivity has been confirmed by western blot analysis of extracts derived from human A431 and K562 cells, canine MDCK cells, mouse brain, rat brain, and recombinant ERK2.

Target Information

ERK1 and ERK2 are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. When growth factors bind to the receptor tyrosine kinase, Ras interacts with Raf, the serine/threonine protein kinase and activates it as well. Once actived, Raf phosphorylates serine residue in 2 further kinases, MEK1/2, which in turn phosphorylates tyrosine/threonine in extracellular-signal regulated kinase (ERK) 1/2. Upon activation, the ERKs either phosphorylate a number of cytoplasmic targets or migrate to the nucleus, where they phosphorylate and activate a number of transcription factors such as c-Fos and Elk-1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Glyoxal-induced disruption of tumor cell progression in breast cancer.

Molecular and clinical oncology

Rong P,Yanchu L,Nianchun G,Qi L,Xianyong L

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Sat Apr 01 00:00:00 EDT 2023

Sialylation of TLR2 initiates osteoclast fusion.

Bone research

Dou C,Zhen G,Dan Y,Wan M,Limjunyawong N,Cao X

13-6200 was used in Immunoprecipitation to reveal that cell recognition mediated by the binding of sialylated TLR2 to Siglec15 initiates cell fusion for osteoclast formation.

Wed Mar 02 00:00:00 EST 2022

Therapeutic Potential of Antimicrobial Peptide PN5 against Multidrug-Resistant E. coli and Anti-Inflammatory Activity in a Septic Mouse Model.

Microbiology spectrum

Kang DD,Park J,Park Y

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Wed Oct 26 00:00:00 EDT 2022

EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways.

Open medicine (Warsaw, Poland)

Ming D,Ma J

13-6200 was used in ELISA, Gel Shift, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to conclude that miR-3666 downregulated EphA3 expression and retarded melanoma malignancy via inactivating ERK1/2 and p38 MAPK pathways.

Tue Jan 03 00:00:00 EST 2023

The Synergistic Effect of Cyclic Tensile Force and Periodontal Ligament Cell-Laden Calcium Silicate/Gelatin Methacrylate Auxetic Hydrogel Scaffolds for Bone Regeneration.

Cells

Lee JJ,Ng HY,Lin YH,Lin TJ,Kao CT,Shie MY

13-6200 was used in Western Blotting to show that novel auxetic scaffolds could be fabricated by combining different aspects of science and technology, in order to improve the future chances of clinical applications for bone regeneration.

Wed Jun 29 00:00:00 EDT 2022

Frustration of endocytosis potentiates compression-induced receptor signaling.

Journal of cell science

Baschieri F,Le Devedec D,Tettarasar S,Elkhatib N,Montagnac G

13-6200 was used in Western Blot to report that compression leads to frustration of CCSs and that CCSs are required to potentiate receptor-mediated signaling in these conditions.

Tue Sep 01 00:00:00 EDT 2020

Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways.

Scientific reports

Kim S,Hong KB,Kim S,Suh HJ,Jo K

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Thu Jul 09 00:00:00 EDT 2020

Creatine and taurine mixtures alleviate depressive-like behaviour in Drosophila melanogaster and mice via regulating Akt and ERK/BDNF pathways.

Scientific reports

Kim S,Hong KB,Kim S,Suh HJ,Jo K

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Thu Jul 09 00:00:00 EDT 2020

Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells.

Oxidative medicine and cellular longevity

Dong G,Huang X,Jiang S,Ni L,Chen S

13-6200 was used in Western Blotting to determine whether continuous stretch induced by portal hypertension may impair the function of endothelial cells (ECs) in the portal vein and aggravate the progress of portal hypertension and explore its mechanism.

Fri Jun 19 00:00:00 EDT 2020

ANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway.

OncoTargets and therapy

Xuan ZB,Wang YJ,Xie J

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Mon Apr 11 00:00:00 EDT 2022

Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells.

Oncology letters

Dong G,Lin XH,Liu HH,Gao DM,Cui JF,Ren ZG,Chen RX

13-6200 was used in Western Blotting to investigate the ability of intermittent hypoxia to alleviate the acute hypoxia-induced increase of VEGF and decrease the pro-angiogenic potential of liver cancer cells.

Thu Aug 01 00:00:00 EDT 2019

Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone.

Frontiers in chemistry

Areiza-Mazo N,Robles J,Zamudio-Rodriguez JA,Giraldez L,Echeverria V,Barrera-Bailon B,Aliev G,Sahebkar A,Ashraf GM,Barreto GE

13-6200 was used in Western Blotting to suggest that ethanolic and acetone extracts from Physalis peruviana have potential to overcome oxidative damage induced by neurotoxic compounds.

Thu Oct 01 00:00:00 EDT 2020

Protective effect of angiotensin II receptor blocker against oxidative stress and inflammation in an oral mucositis experimental model.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Araújo AA,Araújo LS,Medeiros CACX,Leitão RFC,Brito GAC,Costa DVDS,Guerra GCB,Garcia VB,Lima MLS,Araújo Junior RF

13-6200 was used in Western Blotting to evaluate the effect of olmesartan medoxomil, an angiotensin II receptor antagonist, in an oral mucositis experimental model.

Thu Nov 01 00:00:00 EDT 2018

Frustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structures.

Nature communications

Baschieri F,Dayot S,Elkhatib N,Ly N,Capmany A,Schauer K,Betz T,Vignjevic DM,Poincloux R,Montagnac G

13-6200 was used in Western Blotting to study the role of clathrin-coated structures as mechanotransduction structures that sense substrate rigidity independently of cell contractility.

Thu Sep 20 00:00:00 EDT 2018

Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells.

mAbs

Grugan KD,Dorn K,Jarantow SW,Bushey BS,Pardinas JR,Laquerre S,Moores SL,Chiu ML

136200 was used in western blot to elucidate how JNJ-61186372 attenuates therapeutic resistance in patients with epidermal growth factor receptor mutations

Sun Jan 01 00:00:00 EST 2017

Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner.

Scientific reports

Zhang C,Mao HL,Cao Y

13-6200 was used in Western blotting following immunoprecipitation to study the nuclear localisation of symplekin, and the significance of this in tumourigenesis.

Mon Jun 19 00:00:00 EDT 2017

MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways.

Scientific reports

Yan X,Zhu Z,Xu S,Yang LN,Liao XH,Zheng M,Yang D,Wang J,Chen D,Wang L,Liu X,Liu J,Chen RH,Zhou XZ,Lu KP,Liu H

136200 was used in western blot to elucidate the mechanism of Pin1 overexpression in hepatocellular carcinoma

Thu Apr 06 00:00:00 EDT 2017

Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death.

Oncogene

Salas E,Roy S,Marsh T,Rubin B,Debnath J

13-6200 was used in western blot to show that inhibition of the oxidative arm of the pentose phosphate pathway is required for antimalarial-mediated apoptosis.

Thu Jun 02 00:00:00 EDT 2016

Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Nature communications

Blas-Rus N,Bustos-Morán E,Pérez de Castro I,de Cárcer G,Borroto A,Camafeita E,Jorge I,Vázquez J,Alarcón B,Malumbres M,Martín-Cófreces NB,Sánchez-Madrid F

13-6200 was used in Western Blotting to provide a mechanistic explanation as to how Aurora A kinase controls the activation of T lymphocytes during immunological synapse formation.

Tue Apr 19 00:00:00 EDT 2016

Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Nature communications

Blas-Rus N,Bustos-Morán E,Pérez de Castro I,de Cárcer G,Borroto A,Camafeita E,Jorge I,Vázquez J,Alarcón B,Malumbres M,Martín-Cófreces NB,Sánchez-Madrid F

13-6200 was used in Western Blotting to provide a mechanistic explanation as to how Aurora A kinase controls the activation of T lymphocytes during immunological synapse formation.

Tue Apr 19 00:00:00 EDT 2016

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer.

Oncotarget

Aguilera O,Muñoz-Sagastibelza M,Torrejón B,Borrero-Palacios A,Del Puerto-Nevado L,Martínez-Useros J,Rodriguez-Remirez M,Zazo S,García E,Fraga M,Rojo F,García-Foncillas J

136200 was used in western blot to describe the antitumoral mechanism of vitamin C in KRAS mutant colorectal cancer that is related to the Warburg effect

Tue Jul 26 00:00:00 EDT 2016

ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.

Nature cell biology

Murrow L,Malhotra R,Debnath J

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Sun Mar 01 00:00:00 EST 2015

Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells.

Biochimica et biophysica acta

Bernusso VA,Machado-Neto JA,Pericole FV,Vieira KP,Duarte AS,Traina F,Hansen MD,Olalla Saad ST,Barcellos KS

13-6200 was used in western blot to study the effect of Imatinib on VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells

Sun Feb 01 00:00:00 EST 2015

Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.

PloS one

Li LH,Wu P,Lee JY,Li PR,Hsieh WY,Ho CC,Ho CL,Chen WJ,Wang CC,Yen MY,Yang SM,Chen HW

13-6200 was used in western blot to study the effect of Hinokitiol on DNA damage and autophagy in gefitinib-resistant lung adenocarcinoma cells

Mon Apr 13 00:00:00 EDT 2015

Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation.

PloS one

Janardhan SV,Marks R,Gajewski TF

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Wed Dec 30 00:00:00 EST 2015

Post-receptor IGF1 insensitivity restricted to the MAPK pathway in a Silver-Russell syndrome patient with hypomethylation at the imprinting control region on chromosome 11.

European journal of endocrinology

Montenegro LR,Leal AC,Coutinho DC,Valassi HP,Nishi MY,Arnhold IJ,Mendonca BB,Jorge AA

Thu Mar 01 00:00:00 EST 2012

The effects of oral taurine administration on behavior and hippocampal signal transduction in rats.

Amino acids

Iio W,Matsukawa N,Tsukahara T,Toyoda A

13-6200 was used in western blot to study the effects of taurine on antidepressive behaviour and depression-related signaling in the rat hippocampus.

Thu Nov 01 00:00:00 EDT 2012

Insulin signaling in adipose tissue of patients with primary aldosteronism.

Journal of endocrinological investigation

Urbanet R,Pilon C,Giorgino F,Vettor R,Fallo F

13-6200 was used in western blot to examine the phosphorylation of insulin-receptors substrate in various adenoma and adipocytes.

Tue Feb 01 00:00:00 EST 2011

Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation.

Journal of immunology (Baltimore, Md. : 1950)

Driessens G,Zheng Y,Locke F,Cannon JL,Gounari F,Gajewski TF

13-6200 was used in Western Blotting to investigate the mechanism by which β-catenin inhibits T cell activation and cytokine secretion in a mouse model.

Sat Jan 15 00:00:00 EST 2011

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.

PloS one

Janardhan SV,Praveen K,Marks R,Gajewski TF

Published figure using ERK1/ERK2 monoclonal antibody (Product # 13-6200) in Western Blot

Fri Feb 03 00:00:00 EST 2012

Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells.

Biochimica et biophysica acta

Machado-Neto JA,Favaro P,Lazarini M,Costa FF,Olalla Saad ST,Traina F

13-6200 was used in western blot to determine the impact of IRS1 on the BCR-ABL signaling pathways.

Mon Aug 01 00:00:00 EDT 2011

T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha.

Nature immunology

Zha Y,Marks R,Ho AW,Peterson AC,Janardhan S,Brown I,Praveen K,Stang S,Stone JC,Gajewski TF

13-6200 was used in western blot to study the link between Ras activity and T cell anergy

Wed Nov 01 00:00:00 EST 2006

Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway.

Cardiovascular research

Zhu M,Feng J,Lucchinetti E,Fischer G,Xu L,Pedrazzini T,Schaub MC,Zaugg M

13-6200 was used in western blot to test if ischemic post conditioning is protective in remodeled myocardium

Sun Oct 01 00:00:00 EDT 2006

Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration.

Journal of biomedical science

Lo IC,Shih JM,Jiang MJ

13-6200 was used in western blot to examine the effects of MCP-1 on the migration of smooth muscle cells and the pathways modulated

Fri Sep 23 00:00:00 EDT 2005

Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle.

Life sciences

Tsai MH,Jiang MJ

13-6200 was used in western blot to determine the roles of ERK1/2 in modulating intracellular calcium concentrations, calcium sensitivity, and the 20-kDa myosin light chain phosphorylation during contraction activated by U46619 treatment in rat tail arte

Fri Jan 07 00:00:00 EST 2005

GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

The Journal of biological chemistry

Yin G,Zheng Q,Yan C,Berk BC

Fri Jul 29 00:00:00 EDT 2005

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.

Molecular and cellular biology

Martinez-Quiles N,Ho HY,Kirschner MW,Ramesh N,Geha RS

Tue Jun 01 00:00:00 EDT 2004

Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.

Molecular and cellular biology

Martinez-Quiles N,Ho HY,Kirschner MW,Ramesh N,Geha RS

Tue Jun 01 00:00:00 EDT 2004

Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.

The Journal of biological chemistry

Usui S,Sugimoto N,Takuwa N,Sakagami S,Takata S,Kaneko S,Takuwa Y

13-6200 was used in western blot to study SP()-triggered and G(i)-Ras-ERK/p38 MAPK-KLF5-dependent regulation of PDGF gene transcription in vascular smooth muscle cells.

Fri Mar 26 00:00:00 EST 2004

Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5.

The Journal of biological chemistry

Usui S,Sugimoto N,Takuwa N,Sakagami S,Takata S,Kaneko S,Takuwa Y

13-6200 was used in western blot to study SP()-triggered and G(i)-Ras-ERK/p38 MAPK-KLF5-dependent regulation of PDGF gene transcription in vascular smooth muscle cells.

Fri Mar 26 00:00:00 EST 2004

Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts.

The Journal of biological chemistry

Natalicchio A,Laviola L,De Tullio C,Renna LA,Montrone C,Perrini S,Valenti G,Procino G,Svelto M,Giorgino F

Fri Oct 15 00:00:00 EDT 2004

Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts.

The Journal of biological chemistry

Natalicchio A,Laviola L,De Tullio C,Renna LA,Montrone C,Perrini S,Valenti G,Procino G,Svelto M,Giorgino F

Fri Oct 15 00:00:00 EDT 2004

ERK1/2 controls Na,K-ATPase activity and transepithelial sodium transport in the principal cell of the cortical collecting duct of the mouse kidney.

The Journal of biological chemistry

Michlig S,Mercier A,Doucet A,Schild L,Horisberger JD,Rossier BC,Firsov D

Fri Dec 03 00:00:00 EST 2004

Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Derkinderen P,Valjent E,Toutant M,Corvol JC,Enslen H,Ledent C,Trzaskos J,Caboche J,Girault JA

Sat Mar 15 00:00:00 EST 2003

Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein.

Journal of neurochemistry

Hernández M,Barrero MJ,Crespo MS,Nieto ML

13-6200 was used in western blot to determine the effect of lysophosphatidic acid, sphingosine 1-phosphate, and epidermal growth factor on a human astrocytoma cell line.

Sun Oct 01 00:00:00 EDT 2000

Hypothermic stress leads to activation of Ras-Erk signaling.

The Journal of clinical investigation

Chan EY,Stang SL,Bottorff DA,Stone JC

Sat May 01 00:00:00 EDT 1999

Association of the Ras to mitogen-activated protein kinase signal transduction pathway with microfilaments. Evidence for a p185(neu)-containing cell surface signal transduction particle linking the mitogenic pathway to a membrane-microfilament association site.

The Journal of biological chemistry

Carraway CA,Carvajal ME,Carraway KL

Fri Sep 03 00:00:00 EDT 1999

The Journal of biological chemistry

Carraway CA,Carvajal ME,Carraway KL

Fri Sep 03 00:00:00 EDT 1999

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

Science (New York, N.Y.)

Duesbery NS,Webb CP,Leppla SH,Gordon VM,Klimpel KR,Copeland TD,Ahn NG,Oskarsson MK,Fukasawa K,Paull KD,Vande Woude GF

13-6200 was used in western blot to identify the cleavage site for anthrax lethal toxin.

Fri May 01 00:00:00 EDT 1998

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

Proceedings of the National Academy of Sciences of the United States of America

Webb CP,Van Aelst L,Wigler MH,Vande Woude GF

13-6200 was used in immunoprecipitation and western blot to elucidate Ras-mediated tumorigenicity.

Tue Jul 21 00:00:00 EDT 1998

Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity.

Neurochemical research

Korneyev AY

13-6200 was used in western blot to compare the effect of cold water stress on the phosphorylation of brain tau protein in ob/ob and ob/+ mice.

Tue Dec 01 00:00:00 EST 1998

Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils.

The Journal of biological chemistry

Hidari KI,Weyrich AS,Zimmerman GA,McEver RP

13-6200 was used in western blot to test if ligation of PSGL-1 transmits signals into leukocytes.

Fri Nov 07 00:00:00 EST 1997

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

The Journal of biological chemistry

Bird TA,Sleath PR,deRoos PC,Dower SK,Virca GD

Mon Nov 25 00:00:00 EST 1991

Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.

The Journal of biological chemistry

Bird TA,Sleath PR,deRoos PC,Dower SK,Virca GD

Mon Nov 25 00:00:00 EST 1991

Bioinformatics

Protein Aliases: ERK-1; ERK-2; erk1 erk2; ERK1b; ERT1; ERT2; Extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 2; extracellular signal-related kinase 1; extracellular-signal-regulated kinase 2; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 2; MAP kinase 3; MAP kinase isoform p42; MAP kinase isoform p44; MAPK 1; MAPK 2; MAPK 3; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 1; mitogen-activated 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 3; MNK1; p42 MAP Kinase; p42-MAPK; p44 MAP kinase; p44-ERK1; p44-MAPK; pp42/MAP kinase; protein tyrosine kinase ERK2

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Gene Aliases: 9030612K14Rik; AA407128; AU018647; C78273; ERK; ERK-1; ERK-2; ERK1; ERK2; ERT1; ERT2; Esrk1; HS44KDAP; HUMKER1A; Mapk; MAPK1; MAPK2; MAPK3; MNK1; Mtap2k; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM1; PRKM2; PRKM3

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UniProt ID: (Human) P28482, (Human) P27361, (Mouse) P63085, (Rat) P63086, (Rat) P21708, (Mouse) Q63844

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Entrez Gene ID: (Human) 5594, (Dog) 477575, (Human) 5595, (Dog) 100855877, (Mouse) 26413, (Rat) 116590, (Rat) 50689, (Mouse) 26417

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Function(s)

phosphotyrosine binding DNA binding protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity kinase activity phosphatase binding mitogen-activated protein kinase kinase kinase binding identical protein binding scaffold protein binding nucleotide binding protein kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein kinase binding non-receptor serine/threonine protein kinase

Process(es)

Performance Guarantee

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ERK1/ERK2 Monoclonal Antibody (ERK-7D8)

ERK1/ERK2 Antibody (13-6200) in ICC/IF

Product Details

13-6200

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Immunoprecipitation (IP)

Gel Shift (GS)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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