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The predicted MW of ERMN is 33 kDa, while western blot analyses of different tissue lysates using 66605-1-Ig antibody to ERMN detected a 50 kDa single band protein as a result of phosphorylation modification.
Immunogen sequence: MTDVPATFT QAECNGDKPP ENGQQTITKI SEELTDVDSP LPHYRVEPSL EGALTKGSQE ERRKLQGNML LNSSMEDKML KENPEEKLFI VHKAITDLSL QETSADEMTF REGHQWEKIP LSGSNQEIRR QKERITEQPL KEEEDEDRKN KGHQAAEIEW LGFRKPSQAD MLHSKHDEEQ KVWDEEIDDD DDDNCNNDED EVRVIEFKKK HEEVSQFKEE GDASEDSPLS SASSQAVTPD EQPTLGKKSD ISRNAYSR (1-257 aa encoded by BC026345)
ERMIN plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. ERMIN may play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ermin; ermin, ERM-like protein; JN; Juxtanodin
Gene Aliases: A330104H05Rik; AI854460; ermin; ERMN; JN; juxtanodin; KIAA1189; mKIAA1189; RGD1308367
UniProt ID: (Human) Q8TAM6, (Mouse) Q5EBJ4, (Rat) Q5RJL0
Entrez Gene ID: (Pig) 100627261, (Human) 57471, (Mouse) 77767, (Rat) 295619
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