Proteintech

ERp72 Polyclonal Antibody

ERp72 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

ERp72 Antibody (14712-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells, using PDIA4 antibody 14712-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IGG (green).

ERp72 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ERp72 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14712-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 10 publications 10 publications

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

- -

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ERp72 Fusion Protein Ag6431 (294-645 aa encoded by BC000425)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KQVQEFLKD GDDVIIIGVF KGESDPAYQQ YQDAANNLRE DYKFHHTFST EIAKFLKVSQ GQLVVMQPEK FQSKYEPRSH MMDVQGSTQD SAIKDFVLKY ALPLVGHRKV SNDAKRYTRR PLVVVYYSVD FSFDYRAATQ FWRSKVLEVA KDFPEYTFAI ADEEDYAGEV KDLGLSESGE DVNAAILDES GKKFAMEPEE FDSDTLREFV TAFKKGKLKP VIKSQPVPKN NKGPVKVVVG KTFDSIVMDP KKDVLIEFYA PWCGHCKQLE PVYNSLAKKY KGQKGLVIAK MDATANDVPS DRYKVEGFPT IYFAPSGDKK NPVKFEGGDR DLEHLSKFIE EHATKLSRTK EEL (294-645 aa encoded by BC000425)

Target Information

ERp72 is an endoplasmic reticulum luminal protein that is both a stress protein and a member of the protein disulfide isomerase family of proteins. Sequence analysis of ERp72 shows that it shares sequence identity with PDI (protein disulphide isomerase) at three discrete regions, as well as containing the ER retention signal KEEL at its C-terminus. ERp72 is shown to have three copies of sequence believed to be CGHC-containing active sites, which are also found in PDI. These CGHC sites are critical sites that are involved in the protein disulphide isomerization process. These results suggest that ERp72 is a newly described member of the family of CGHC-containing proteins that functions as a molecular chaperone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.

Journal of experimental & clinical cancer research : CR

Tu Z,Wang C,Hu Q,Tao C,Fang Z,Lin L,Lei K,Luo M,Sheng Y,Long X,Li J,Wu L,Huang K,Zhu X

Thu Mar 30 00:00:00 EDT 2023

Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.

Journal of experimental & clinical cancer research : CR

Tu Z,Wang C,Hu Q,Tao C,Fang Z,Lin L,Lei K,Luo M,Sheng Y,Long X,Li J,Wu L,Huang K,Zhu X

Thu Mar 30 00:00:00 EDT 2023

Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.

Journal of experimental & clinical cancer research : CR

Tu Z,Wang C,Hu Q,Tao C,Fang Z,Lin L,Lei K,Luo M,Sheng Y,Long X,Li J,Wu L,Huang K,Zhu X

Thu Mar 30 00:00:00 EDT 2023

Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.

Journal of experimental & clinical cancer research : CR

Tu Z,Wang C,Hu Q,Tao C,Fang Z,Lin L,Lei K,Luo M,Sheng Y,Long X,Li J,Wu L,Huang K,Zhu X

Thu Mar 30 00:00:00 EDT 2023

SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response.

bioRxiv : the preprint server for biology

Davies JP,Sivadas A,Keller KR,Wojcikiewicz RJH,Plate L

Mon Jun 12 00:00:00 EDT 2023

PDIA4 confers resistance to ferroptosis via induction of ATF4/SLC7A11 in renal cell carcinoma.

Cell death & disease

Kang L,Wang D,Shen T,Liu X,Dai B,Zhou D,Shen H,Gong J,Li G,Hu Y,Wang P,Mi X,Zhang Y,Tan X

Sat Mar 11 00:00:00 EST 2023

Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation.

Oncogene

Fang J,Zhang Y,Huang C,Lu R,Yu J,Chen R,Wang Y,Zhao X,Yu J,Huang J

Wed Mar 01 00:00:00 EST 2023

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors.

Cells

Mesgarzadeh JS,Romine IC,Smith-Cohen EM,Grandjean JMD,Kelly JW,Genereux JC,Wiseman RL

Tue May 17 00:00:00 EDT 2022

Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis.

Science advances

Chen HS,Wang J,Li HH,Wang X,Zhang SQ,Deng T,Li YK,Zou RS,Wang HJ,Zhu R,Xie WL,Zhao G,Wang F,Chen JG

Fri Dec 02 00:00:00 EST 2022

A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines.

The Journal of biological chemistry

Mideksa YG,Aschenbrenner I,Fux A,Kaylani D,Weiß CAM,Nguyen TA,Bach NC,Lang K,Sieber SA,Feige MJ

Thu Dec 01 00:00:00 EST 2022

High expression of PDIA4 promotes malignant cell behavior and predicts reduced survival in cervical cancer.

Oncology reports

Xing F,Song Z,Cheng Z

Sat Oct 01 00:00:00 EDT 2022

High expression of PDIA4 promotes malignant cell behavior and predicts reduced survival in cervical cancer.

Oncology reports

Xing F,Song Z,Cheng Z

Sat Oct 01 00:00:00 EDT 2022

Albumin (ALB) and protein disulfide isomerase family A member 4 (PDIA4) are novel markers to predict sperm freezability of Erhualian boar.

Cryobiology

Tong S,Yin C,Ge Y,Ren Z,Tao J,Liu Y

Thu Dec 01 00:00:00 EST 2022

Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs.

bioRxiv : the preprint server for biology

Almasy KM,Davies JP,Plate L

Mon Mar 08 00:00:00 EST 2021

Identification and detection of mecciRNAs.

Methods (San Diego, Calif.)

Liu X,Yang Y,Shan G

Wed Dec 01 00:00:00 EST 2021

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

Molecular metabolism

Chhabra NF,Amend AL,Bastidas-Ponce A,Sabrautzki S,Tarquis-Medina M,Sachs S,Rubey M,Lorenz-Depiereux B,Feuchtinger A,Bakhti M,Lickert H,Przemeck GKH,Hrabě de Angelis M

Wed Dec 01 00:00:00 EST 2021

Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.

Molecular & cellular proteomics : MCP

Almasy KM,Davies JP,Plate L

Mon Jan 10 00:00:00 EST 2022

Thyroglobulin Interactome Profiling Defines Altered Proteostasis Topology Associated With Thyroid Dyshormonogenesis.

Molecular & cellular proteomics : MCP

Wright MT,Kouba L,Plate L

Mon Mar 14 00:00:00 EDT 2022

miRNA-mRNA Regulatory Network Reveals miRNAs in HCT116 in Response to Folic Acid Deficiency via Regulating Vital Genes of Endoplasmic Reticulum Stress Pathway.

BioMed research international

Lu L,Zhao H,Liu J,Zhang Y,Wang X

Mon May 31 00:00:00 EDT 2021

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies.

bioRxiv : the preprint server for biology

Davies JP,Almasy KM,McDonald EF,Plate L

Tue Jul 14 00:00:00 EDT 2020

Identification of mecciRNAs and their roles in the mitochondrial entry of proteins.

Science China. Life sciences

Liu X,Wang X,Li J,Hu S,Deng Y,Yin H,Bao X,Zhang QC,Wang G,Wang B,Shi Q,Shan G

Thu Oct 01 00:00:00 EDT 2020

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.

ACS infectious diseases

Davies JP,Almasy KM,McDonald EF,Plate L

Fri Dec 11 00:00:00 EST 2020

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.

eLife

Jang I,Pottekat A,Poothong J,Yong J,Lagunas-Acosta J,Charbono A,Chen Z,Scheuner DL,Liu M,Itkin-Ansari P,Arvan P,Kaufman RJ

Tue Jun 11 00:00:00 EDT 2019

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein.

Cell chemical biology

Plate L,Rius B,Nguyen B,Genereux JC,Kelly JW,Wiseman RL

Thu Jul 18 00:00:00 EDT 2019

N-Glycosylation is required for FDNC5 stabilization and irisin secretion.

The Biochemical journal

Nie Y,Liu D

Thu Sep 07 00:00:00 EDT 2017

N-Glycosylation is required for FDNC5 stabilization and irisin secretion.

The Biochemical journal

Nie Y,Liu D

Thu Sep 07 00:00:00 EDT 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 EST 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 EST 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 EST 2017

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Oncotarget

Samanta S,Tamura S,Dubeau L,Mhawech-Fauceglia P,Miyagi Y,Kato H,Lieberman R,Buckanovich RJ,Lin YG,Neamati N

Tue Nov 28 00:00:00 EST 2017

Mapping wild-type and R345W fibulin-3 intracellular interactomes.

Experimental eye research

Hulleman JD,Genereux JC,Nguyen A

Thu Dec 01 00:00:00 EST 2016

Mapping wild-type and R345W fibulin-3 intracellular interactomes.

Experimental eye research

Hulleman JD,Genereux JC,Nguyen A

Thu Dec 01 00:00:00 EST 2016

Identification and characterization of an endoplasmic reticulum localization motif.

Biochemical and biophysical research communications

Nie YW,Wang M,Zhang P,Huan L,Liu DJ

Fri Apr 22 00:00:00 EDT 2016

Identification and characterization of an endoplasmic reticulum localization motif.

Biochemical and biophysical research communications

Nie YW,Wang M,Zhang P,Huan L,Liu DJ

Fri Apr 22 00:00:00 EDT 2016

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

eLife

Plate L,Cooley CB,Chen JJ,Paxman RJ,Gallagher CM,Madoux F,Genereux JC,Dobbs W,Garza D,Spicer TP,Scampavia L,Brown SJ,Rosen H,Powers ET,Walter P,Hodder P,Wiseman RL,Kelly JW

Wed Jul 20 00:00:00 EDT 2016

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

eLife

Plate L,Cooley CB,Chen JJ,Paxman RJ,Gallagher CM,Madoux F,Genereux JC,Dobbs W,Garza D,Spicer TP,Scampavia L,Brown SJ,Rosen H,Powers ET,Walter P,Hodder P,Wiseman RL,Kelly JW

Wed Jul 20 00:00:00 EDT 2016

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Cell

Zhang X,Zuo X,Yang B,Li Z,Xue Y,Zhou Y,Huang J,Zhao X,Zhou J,Yan Y,Zhang H,Guo P,Sun H,Guo L,Zhang Y,Fu XD

Thu Jul 31 00:00:00 EDT 2014

MicroRNA directly enhances mitochondrial translation during muscle differentiation.

Cell

Zhang X,Zuo X,Yang B,Li Z,Xue Y,Zhou Y,Huang J,Zhao X,Zhou J,Yan Y,Zhang H,Guo P,Sun H,Guo L,Zhang Y,Fu XD

Thu Jul 31 00:00:00 EDT 2014

Inhibition by imatinib of expression of O-glycan-related glycosyltransferases and tumor-associated carbohydrate antigens in the K562 human leukemia cell line.

Asian Pacific journal of cancer prevention : APJCP

Sun QC,Liu MB,Shen HJ,Jiang Z,Xu L,Gao LP,Ni JL,Wu SL

Tue Oct 22 00:00:00 EDT 2013

Inhibition by imatinib of expression of O-glycan-related glycosyltransferases and tumor-associated carbohydrate antigens in the K562 human leukemia cell line.

Asian Pacific journal of cancer prevention : APJCP

Sun QC,Liu MB,Shen HJ,Jiang Z,Xu L,Gao LP,Ni JL,Wu SL

Tue Oct 22 00:00:00 EDT 2013

Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.

The Journal of biological chemistry

Ye H,Zhao T,Tan YL,Liu J,Pallen CJ,Xiao ZC

Fri Jul 22 00:00:00 EDT 2011

Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.

The Journal of biological chemistry

Ye H,Zhao T,Tan YL,Liu J,Pallen CJ,Xiao ZC

Fri Jul 22 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: CaBP2; calcium binding protein, intestinal; Calcium-binding protein 2; EC 5.3.4.1; endoplasmic reticulum protein 72; Endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; protein disu; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; Protein disulfide-isomerase A4; Protein ERp-72; testicular tissue protein Li 137

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Gene Aliases: AI987846; Cabp2; Cai; ERp-72; ERP70; ERP72; PDIA4

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UniProt ID: (Human) P13667, (Mouse) P08003, (Rat) P38659

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Entrez Gene ID: (Human) 9601, (Mouse) 12304, (Rat) 116598

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Function(s)

protein disulfide isomerase activity protein binding poly(A) RNA binding isomerase activity chaperone

Process(es)

protein folding protein secretion response to endoplasmic reticulum stress cell redox homeostasis chaperone-mediated protein folding positive regulation of protein folding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ERp72 Polyclonal Antibody

ERp72 Antibody (14712-1-AP) in ICC/IF

Product Details

14712-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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