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Product Details
14007-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ESR2 Fusion Protein Ag5103 (1-323 aa encoded by BC024181)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDIKNSPSS LNSPSSYNCS QSILPLEHGS IYIPSSYVDS HHEYPAMTFY SPAVMNYSIP SNVTNLEGGP GRQTTSPNVL WPTPGHLSPL VVHRQLSHLY AEPQKSPWCE ARSLEHTLPV NRETLKRKVS GNRCASPVTG PGSKRDAHFC AVCSDYASGY HYGVWSCEGC KAFFKRSIQG HNDYICPATN QCTIDKNRRK SCQACRLRKC YEVGMVKCGS RRERCGYRLV RRQRSADEQL HCAGKAKRSG GHAPRVRELL LDALSPEQLV LTLLEAEPPH VLISRPSAPF TEASMMMSLT KLADKELVHM ISWAKKIPGM RGNA (1-323 aa encoded by BC024181)
Target Information
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ER beta; ER-beta; estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta
Gene Aliases: ER-BETA; ER[b]; Erb; Erb2; ERbeta; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2
UniProt ID: (Human) Q92731, (Mouse) O08537, (Rat) Q62986
Entrez Gene ID: (Human) 2100, (Mouse) 13983, (Rat) 25149
core promoter sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
protein binding
drug binding
zinc ion binding
enzyme binding
estrogen receptor activity
estrogen response element binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
peroxisome proliferator activated receptor binding
receptor antagonist activity
estradiol binding
steroid hormone binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
lipid binding
hormone binding
sequence-specific DNA binding
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
behavioral fear response
neuron migration
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
brain development
learning or memory
negative regulation of cell proliferation
hormone-mediated apoptotic signaling pathway
intracellular steroid hormone receptor signaling pathway
intracellular estrogen receptor signaling pathway
response to testosterone
regulation of cell proliferation
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
regulation of neuron apoptotic process
estrous cycle
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of behavior
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
Sertoli cell proliferation
uterus development
vagina development
negative regulation of cell death
prostate gland epithelium morphogenesis
epithelial cell maturation involved in prostate gland development
negative regulation of androgen receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
negative regulation of neuron death
negative regulation of feeding behavior
negative regulation of reactive oxygen species metabolic process
transcription initiation from RNA polymerase II promoter
signal transduction
cell-cell signaling
response to water deprivation
response to activity
response to insecticide
cerebellum development
amygdala development
hypothalamus development
negative regulation of cell growth
prostate gland development
response to nutrient levels
response to genistein
cellular response to drug
response to estrogen
response to human chorionic gonadotropin
response to ethanol
positive regulation of vasodilation
Sertoli cell development
cellular response to magnetism
cellular response to estradiol stimulus
response to dexamethasone
extracellular negative regulation of signal transduction
response to salt
response to bisphenol A
male gonad development
female gonad development
response to hormone
response to organic cyclic compound
response to estradiol
response to drug
cellular response to organic cyclic compound
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