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Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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This antibody is predicted to react with Monkey, Horse, Pig, Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ERR beta-2; ERR-beta; ERRbeta; ERRbeta-2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2
Gene Aliases: DFNB35; ERR2; ERRb; ERRB2; ESRL2; ESRRB; NR3B2
UniProt ID: (Human) O95718
Entrez Gene ID: (Human) 2103
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