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Product Details
66598-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
4F2D4
Immunogen
ETS1 Fusion Protein Ag2127 (1-272 aa encoded by BC017314)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKAAVDLKP TLTIIKTEKV DLELFPSPDM ECADVPLLTP SSKEMMSQAL KATFSGFTKE QQRLGIPKDP RQWTETHVRD WVMWAVNEFS LKGVDFQKFC MNGAALCALG KDCFLELAPD FVGDILWEHL EILQKEDVKP YQVNGVNPAY PESRYTSDYF ISYGIEHAQC VPPSEFSEPS FITESYQTLH PISSEELLSL KYENDYPSVI LRDPLQTDTL QNDYFAIKQE VVTPDNMCMG RTSRGKLGGQ DSFESIESYD SCGQEMGKEE KQT (1-272 aa encoded by BC017314)
Target Information
ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1
Gene Aliases: c-ets-1; ETS-1; ETS1; Etsoncb; EWSR2; p54; Tpl1
UniProt ID: (Human) P14921, (Rat) P41156
Entrez Gene ID: (Human) 2113, (Rat) 24356
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
histone acetyltransferase binding
identical protein binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
response to hypoxia
immune response
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
response to mechanical stimulus
positive regulation of endothelial cell migration
regulation of extracellular matrix disassembly
hypothalamus development
pituitary gland development
PML body organization
response to estradiol
response to laminar fluid shear stress
estrous cycle
positive regulation of erythrocyte differentiation
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell motility
negative regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of cellular component movement
angiogenesis involved in wound healing
pri-miRNA transcription from RNA polymerase II promoter
cellular response to hydrogen peroxide
response to interleukin-1
positive regulation of leukocyte adhesion to vascular endothelial cell
immune system process
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
response to wounding
cell differentiation
positive regulation of cell migration
regulation of apoptotic process
negative regulation of cell cycle
response to antibiotic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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