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Invitrogen
ETV4 Monoclonal Antibody (1A2G3)
Product Details
MA5-15424
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2G3
Immunogen
Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_10977392
Product Specific Information
MA5-15424 targets ETV4 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15424 immunogen is purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.
MA5-15424 detects ETV4 which has a predicted molecular weight of approximately 54kDa.
Target Information
ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU. 1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU. 1, although PU. 1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adenovirus E1A enhancer-binding protein; E1A F; E1A-F; ETS translocation variant 4; ets variant gene 4 (E1A enhancer-binding protein, E1AF); EWS protein/E1A enhancer binding protein chimera; PEA3 protein; Polyomavirus enhancer activator 3 homolog; Protein PEA3
Gene Aliases: E1A-F; E1AF; ETV4; PEA3; PEAS3
UniProt ID: (Human) P43268
Entrez Gene ID: (Human) 2118
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
winged helix/forkhead transcription factor
transcription from RNA polymerase II promoter
motor neuron axon guidance
cell differentiation
negative regulation of mammary gland epithelial cell proliferation
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
branching involved in mammary gland duct morphogenesis
regulation of branching involved in mammary gland duct morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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