Proteintech

EXO1 Polyclonal Antibody

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EXO1 Antibody (16253-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 16253-1-AP) EXO1 antibody at dilution of 1:8,000 incubated at room temperature for 1.5 hours.

EXO1 Antibody in Immunoprecipitation (IP)

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Product Details

16253-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXO1 Fusion Protein Ag9253 (496-846 aa encoded by BC007491)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AVVVPGTRS RFFCSSDSTD CVSNKVSIQP LDETAVTDKE NNLHESEYGD QEGKRLVDTD VARNSSDDIP NNHIPGDHIP DKATVFTDEE SYSFESSKFT RTISPPTLGT LRSCFSWSGG LGDFSRTPSP SPSTALQQFR RKSDSPTSLP ENNMSDVSQL KSEESSDDES HPLREGACSS QSQESGEFSL QSSNASKLSQ CSSKDSDSEE SDCNIKLLDS QSDQTSKLCL SHFSKKDTPL RNKVPGLYKS SSADSLSTTK IKPLGPARAS GLSKKPASIQ KRKHHNAENK PGLQIKLNEL WKNFGFKKDS EKLPPCKKPL SPVRDNIQLT PEAEEDIFNK PECGRVQRAI FQ (496-846 aa encoded by BC007491)

Target Information

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.

Journal of cardiovascular translational research

Zou X,Liao Y,Liu Z,Xu X,Sun W,Qin H,Wang H,Liu J,Jing T

Wed Feb 01 00:00:00 EST 2023

Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5' C-Rich Overhangs and Recruitment of TERRA.

Frontiers in genetics

Nelson CB,Alturki TM,Luxton JJ,Taylor LE,Maranon DG,Muraki K,Murnane JP,Bailey SM

Wed Apr 14 00:00:00 EDT 2021

Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.

eLife

Shen B,Chapman JH,Custance MF,Tricola GM,Jones CE,Furano AV

Mon Jan 06 00:00:00 EST 2020

DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.

Nucleic acids research

Tammaro M,Liao S,Beeharry N,Yan H

Fri Jan 08 00:00:00 EST 2016

DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway.

Nucleic acids research

Tammaro M,Liao S,Beeharry N,Yan H

Fri Jan 08 00:00:00 EST 2016

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

PLoS genetics

Wu Y,Lee SH,Williamson EA,Reinert BL,Cho JH,Xia F,Jaiswal AS,Srinivasan G,Patel B,Brantley A,Zhou D,Shao L,Pathak R,Hauer-Jensen M,Singh S,Kong K,Wu X,Kim HS,Beissbarth T,Gaedcke J,Burma S,Nickoloff JA,Hromas RA

Tue Dec 01 00:00:00 EST 2015

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair.

PLoS genetics

Tue Dec 01 00:00:00 EST 2015

PCNA promotes processive DNA end resection by Exo1.

Nucleic acids research

Chen X,Paudyal SC,Chin RI,You Z

Fri Nov 01 00:00:00 EDT 2013

PCNA promotes processive DNA end resection by Exo1.

Nucleic acids research

Chen X,Paudyal SC,Chin RI,You Z

Fri Nov 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: Exonuclease 1; Exonuclease I; hExo1; hExoI; mExo1; rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1

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Gene Aliases: 5730442G03Rik; EXO1; EXOI; HEX1; hExoI; Msa

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UniProt ID: (Human) Q9UQ84, (Mouse) Q9QZ11

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Entrez Gene ID: (Human) 9156, (Mouse) 26909

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Function(s)

DNA binding chromatin binding RNA-DNA hybrid ribonuclease activity exonuclease activity protein binding 5'-3' exonuclease activity 5'-3' exodeoxyribonuclease activity single-stranded DNA 5'-3' exodeoxyribonuclease activity metal ion binding flap endonuclease activity double-stranded DNA 5'-3' exodeoxyribonuclease activity catalytic activity nuclease activity endonuclease activity hydrolase activity hydrolase activity, acting on ester bonds phosphoric ester hydrolase activity structure-specific DNA binding T/G mismatch-specific endonuclease activity retroviral 3' processing activity exodeoxyribonuclease

Process(es)

DNA synthesis involved in DNA repair strand displacement humoral immune response mediated by circulating immunoglobulin DNA replication DNA repair mismatch repair DNA recombination somatic hypermutation of immunoglobulin genes isotype switching meiotic cell cycle RNA phosphodiester bond hydrolysis, endonucleolytic regulation of signal transduction by p53 class mediator immune system process nucleobase-containing compound metabolic process cellular response to DNA damage stimulus nucleic acid phosphodiester bond hydrolysis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EXO1 Polyclonal Antibody

EXO1 Antibody (16253-1-AP) in WB

Product Details

16253-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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