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Product Details
16731-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
EXOSC10 Fusion Protein Ag10189 (540-885 aa encoded by BC073788)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IAEELPKEP QGIIACCNPV PPLVRQQINE MHLLIQQARE MPLLKSEVAA GVKKSGPLPS AERLENVLFG PHDCSHAPPD GYPIIPTSGS VPVQKQASLF PDEKEDNLLG TTCLIATAVI TLFNEPSAED SKKGPLTVAQ KKAQNIMESF ENPFRMFLPS LGHRAPVSQA AKFDPSTKIY EISNRWKLAQ VQVQKDSKEA VKKKAAEQTA AREQAKEACK AAAEQAISVR QQVVLENAAK KRERATSDPR TTEQKQEKKR LKISKKPKDP EPPEKEFTPY DYSQSDFKAF AGNSKSKVSS QFDPNKQTPS GKKCIAAKKI KQSVGNKSMS FPTGKSDRGF RYNWPQR (540-885 aa encoded by BC073788 )
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; Exosome complex component 10; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog
Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780, (Mouse) P56960
Entrez Gene ID: (Human) 5394, (Mouse) 50912
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
dosage compensation by inactivation of X chromosome
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
histone mRNA catabolic process
nuclear retention of unspliced pre-mRNA at the site of transcription
RNA phosphodiester bond hydrolysis, exonucleolytic
nucleobase-containing compound metabolic process
RNA processing
cellular metabolic process
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