Proteintech

EXOSC8 Polyclonal Antibody

EXOSC8 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 13

EXOSC8 Antibody (11979-1-AP) in ICC/IF

Immunofluorescent analysis of 4T1 cells, using EXOSC8 antibody 11979-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

EXOSC8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

EXOSC8 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11979-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOSC8 Fusion Protein Ag2605 (1-276 aa encoded by BC020773)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAGFKTVE PLEYYRRFLK ENCRPDGREL GEFRTTTVNI GSISTADGSA LVKLGNTTVI CGVKAEFAAP STDAPDKGYV VPNVDLPPLC SSRFRSGPPG EEAQVASQFI ADVIENSQII QKEDLCISPG KLVWVLYCDL ICLDYDGNIL DACTFALLAA LKNVQLPEVT INEETALAEV NLKKKSYLNI RTHPVATSFA VFDDTLLIVD PTGEEEHLAT GTLTIVMDEE GKLCCLHKPG GSGLTGAKLQ DCMSRAVTRH KEVKKLMDEV IKSMKPK (1-276 aa encoded by BC020773)

Target Information

This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication.

Life science alliance

Moll T,Odon V,Harvey C,Collins MO,Peden A,Franklin J,Graves E,Marshall JN,Dos Santos Souza C,Zhang S,Castelli L,Hautbergue G,Azzouz M,Gordon D,Krogan N,Ferraiuolo L,Snyder MP,Shaw PJ,Rehwinkel J,Cooper-Knock J

Sun Jan 01 00:00:00 EST 2023

Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.

Nature

Shan L,Xu G,Yao RW,Luan PF,Huang Y,Zhang PH,Pan YH,Zhang L,Gao X,Li Y,Cao SM,Gao SX,Yang ZH,Li S,Yang LZ,Wang Y,Wong CCL,Yu L,Li J,Yang L,Chen LL

Wed Mar 01 00:00:00 EST 2023

New subtype of PCH1C caused by novel EXOSC8 variants in a 16-year-old Spanish patient.

Neuromuscular disorders : NMD

Rodríguez-García ME,Cotrina-Vinagre FJ,Bellusci M,Merino-López A,Chumilla-Calzada S,García-Silva MT,Martínez-Azorín F

Sun Aug 01 00:00:00 EDT 2021

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities.

Nature communications

Nichols CA,Gibson WJ,Brown MS,Kosmicki JA,Busanovich JP,Wei H,Urbanski LM,Curimjee N,Berger AC,Gao GF,Cherniack AD,Dhe-Paganon S,Paolella BR,Beroukhim R

Wed May 20 00:00:00 EDT 2020

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

Nature communications

Boczonadi V,Müller JS,Pyle A,Munkley J,Dor T,Quartararo J,Ferrero I,Karcagi V,Giunta M,Polvikoski T,Birchall D,Princzinger A,Cinnamon Y,Lützkendorf S,Piko H,Reza M,Florez L,Santibanez-Koref M,Griffin H,Schuelke M,Elpeleg O,Kalaydjieva L,Lochmüller H,Elliott DJ,Chinnery PF,Edvardson S,Horvath R

Thu Jul 03 00:00:00 EDT 2014

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.

Nature communications

Thu Jul 03 00:00:00 EDT 2014

Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.

PloS one

Saeki M,Egusa H,Kamano Y,Kakihara Y,Houry WA,Yatani H,Noguchi S,Kamisaki Y

Fri Feb 07 00:00:00 EST 2014

Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA.

PloS one

Saeki M,Egusa H,Kamano Y,Kakihara Y,Houry WA,Yatani H,Noguchi S,Kamisaki Y

Fri Feb 07 00:00:00 EST 2014

Bioinformatics

Protein Aliases: CBP-interacting protein 3; Exosome complex component RRP43; exosome complex exonuclease RRP43; Exosome component 8; OIP-2; Opa interacting protein 2; Opa-interacting protein 2; p9; Ribosomal RNA-processing protein 43; RP11-421P11.3

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Gene Aliases: 2310032N20Rik; bA421P11.3; CIP3; EAP2; EXOSC8; mKIAA4013; OIP2; p9; PCH1C; RRP43; Rrp43p

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UniProt ID: (Human) Q96B26, (Mouse) Q9D753

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Entrez Gene ID: (Human) 11340, (Mouse) 69639, (Rat) 295050

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Function(s)

exoribonuclease activity protein binding AU-rich element binding RNA binding RNA metabolism protein exoribonuclease nucleic acid metabolism protein

Process(es)

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing biological_process nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing regulation of mRNA stability exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay nuclear mRNA surveillance nuclear polyadenylation-dependent rRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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EXOSC8 Polyclonal Antibody

EXOSC8 Antibody (11979-1-AP) in ICC/IF

Product Details

11979-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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