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Product Details
MA5-35459
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC0921
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 150-254 of human Emerin/EMD (P50402)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849360
Product Specific Information
Immunogen sequence: RERPMYGRDS AYQSITHYRP VSASRSSLDL SYYPTSSSTS FMSSSSSSSS WLTRRAIRPE NRAPGAGLGQ DRQVPLWGQL LLFLVFVIVL FFIYHFMQAE EGNPF
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Emerin; LEM domain containing 5
Gene Aliases: AW550900; EDMD; EMD; LEMD5; STA
UniProt ID: (Human) P50402, (Mouse) O08579, (Rat) Q63190
Entrez Gene ID: (Human) 2010, (Mouse) 13726, (Rat) 25437
muscle contraction
mitotic nuclear envelope disassembly
mitotic nuclear envelope reassembly
muscle organ development
negative regulation of catenin import into nucleus
skeletal muscle cell differentiation
positive regulation of protein export from nucleus
negative regulation of fibroblast proliferation
regulation of canonical Wnt signaling pathway
cellular response to growth factor stimulus
cell-cell adhesion
nuclear envelope reassembly
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