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Product Details
MA1-83134
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3G10
Immunogen
Synthetic peptide corresponding to the c-terminal region of human endothelin (C,H,L,D,I,I,W), conjugated to BSA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_931678
Product Specific Information
For IHC applications, frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
Rat anti Human endothelin antibody, clone 3G10 reacts with the C terminal of endothelins 1, 2 and 3.
Target Information
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Big endothelin 1; Big ET; Big ET 1; Big ET1; BigET; Endothelin-1; Et; PPET1; Preproendothelin-1
Gene Aliases: ARCND3; EDN1; ET1; HDLCQ7; PPET1; QME
UniProt ID: (Human) P05305
Entrez Gene ID: (Human) 1906
negative regulation of transcription from RNA polymerase II promoter
prostaglandin biosynthetic process
patterning of blood vessels
in utero embryonic development
histamine secretion
regulation of systemic arterial blood pressure by endothelin
regulation of pH
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
cell-cell signaling
heart development
respiratory gaseous exchange
body fluid secretion
positive regulation of cell proliferation
dorsal/ventral pattern formation
response to ozone
multicellular organism aging
positive regulation of heart rate
positive regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
positive regulation of receptor biosynthetic process
neural crest cell development
phosphatidylinositol 3-kinase signaling
response to activity
artery smooth muscle contraction
vein smooth muscle contraction
glucose transport
cell growth
regulation of vasoconstriction
sensory perception of pain
calcium-mediated signaling
peptide hormone secretion
nitric oxide transport
negative regulation of blood coagulation
positive regulation of cell migration
neutrophil chemotaxis
negative regulation of cAMP biosynthetic process
phospholipase D-activating G-protein coupled receptor signaling pathway
negative regulation of cellular protein metabolic process
positive regulation of prostaglandin secretion
response to lipopolysaccharide
response to testosterone
negative regulation of smooth muscle cell apoptotic process
response to prostaglandin F
response to nicotine
cellular response to drug
positive regulation of urine volume
positive regulation of renal sodium excretion
response to muscle stretch
epithelial fluid transport
vasoconstriction
protein kinase C deactivation
middle ear morphogenesis
positive regulation of odontogenesis
superoxide anion generation
rhythmic excitation
response to amino acid
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
response to leptin
leukocyte activation
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
positive regulation of hormone secretion
negative regulation of hormone secretion
inositol phosphate-mediated signaling
positive regulation of smooth muscle cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
cartilage development
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
negative regulation of nitric-oxide synthase biosynthetic process
membrane depolarization
regulation of sensory perception of pain
maternal process involved in parturition
positive regulation of sarcomere organization
positive regulation of prostaglandin-endoperoxide synthase activity
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of chemokine-mediated signaling pathway
cellular response to calcium ion
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
cellular response to glucocorticoid stimulus
cellular response to mineralocorticoid stimulus
cellular response to fatty acid
cellular response to hypoxia
response to dexamethasone
cellular response to transforming growth factor beta stimulus
response to salt
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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