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Invitrogen
Eotaxin Monoclonal Antibody (43911)
Advanced Verification
This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
Eotaxin Antibody (MA5-23831) in IHC (P)
Immunohistochemical analysis of Eotaxin in immersion fixed paraffin-embedded sections of human colon. Samples were incubated with Eotaxin monoclonal antibody (Product # MA5-23831) using a dilution of 15 µg/mL for 1 hour at room temperature followed by Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody. Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localize... View More
Product Details
MA5-23831
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
43911
Immunogen
E. coli-derived recombinant human CCL11/Eotaxin Gly24-Pro97
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608604
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C motif chemokine 11; chemokine (C-C motif) ligand 11; Eosinophil chemotactic protein; Eotaxin; Eotaxin 1; eotaxin-1; Eotaxin1; MGC22554; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin); Small-inducible cytokine A11
Gene Aliases: CCL11; SCYA11
UniProt ID: (Human) P51671
Entrez Gene ID: (Human) 6356
positive regulation of endothelial cell proliferation
chronic inflammatory response
monocyte chemotaxis
mast cell chemotaxis
protein phosphorylation
cellular calcium ion homeostasis
chemotaxis
inflammatory response
cytoskeleton organization
actin filament organization
cell adhesion
signal transduction
G-protein coupled receptor signaling pathway
regulation of cell shape
response to radiation
response to virus
positive regulation of cell migration
neutrophil chemotaxis
positive regulation of actin filament polymerization
response to interleukin-13
positive regulation of GTPase activity
positive regulation of angiogenesis
eosinophil chemotaxis
lymphocyte chemotaxis
positive regulation of inflammatory response
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
chemokine-mediated signaling pathway
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
response to interleukin-4
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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