Product References
Exosomal miR-532-5p induced by long-term exercise rescues blood-brain barrier function in 5XFAD mice via downregulation of EPHA4.
Aging cell
Liang X,Fa W,Wang N,Peng Y,Liu C,Zhu M,Tian N,Wang Y,Han X,Qiu C,Hou T,Du Y
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Sun Jan 01 00:00:00 EST 2023
EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes.
iScience
Dennys C,Baggio C,Rodrigo R,Roussel F,Kulinich A,Heintzman S,Fox A,Kolb SJ,Shaw PJ,Ethell IM,Pellecchia M,Meyer KC
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Fri Sep 16 00:00:00 EDT 2022
EphA4 targeting agents protect motor neurons from cell death induced by amyotrophic lateral sclerosis -astrocytes.
iScience
Dennys C,Baggio C,Rodrigo R,Roussel F,Kulinich A,Heintzman S,Fox A,Kolb SJ,Shaw PJ,Ethell IM,Pellecchia M,Meyer KC
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Fri Sep 16 00:00:00 EDT 2022
SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Matsuura K,Kobayashi S,Konno K,Yamasaki M,Horiuchi T,Senda T,Hayashi T,Satoh K,Arima-Yoshida F,Iwasaki K,Negishi L,Yasui-Shimizu N,Kohu K,Kawahara S,Kirino Y,Nakamura T,Watanabe M,Yamamoto T,Manabe T,Akiyama T
37-1600 was used in Western Blotting to perform expression analyses using super-resolution microscopy (SRM) in mouse brain and demonstrated that SIPA1L1 is mainly localized to general submembranous regions in neurons, but surprisingly, not to PSD. Our screening for physiological interactors of SIPA1L1 in mouse brain identified spinophilin and neurabin-1, regulators of G-protein-coupled receptor (GPCR) signaling, but rejected PSD-95/NMDA-R-complex components.
Wed Mar 23 00:00:00 EDT 2022
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4.
Cell chemical biology
Wolff DW,Deng Z,Bianchi-Smiraglia A,Foley CE,Han Z,Wang X,Shen S,Rosenberg MM,Moparthy S,Yun DH,Chen J,Baker BK,Roll MV,Magiera AJ,Li J,Hurley E,Feltri ML,Cox AO,Lee J,Furdui CM,Liu L,Bshara W,LaConte LEW,Kandel ES,Pasquale EB,Qu J,Hedstrom L,Nikiforov MA
37-1600 was used in Western Blotting to demonstrate that GMPR plays a key role in EPHA4-mediated RAC1 suppression.
Thu Jun 16 00:00:00 EDT 2022
NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
Journal of medicinal chemistry
Baggio C,Kulinich A,Dennys CN,Rodrigo R,Meyer K,Ethell I,Pellecchia M
37-1600 was used in Western Blotting to show that the data form a strong foundation for the translation of these agents for the treatment of ALS and potentially other human diseases.
Thu Aug 12 00:00:00 EDT 2021
Environmental enrichment during the chronic phase after experimental stroke promotes functional recovery without synergistic effects of EphA4 targeted therapy.
Human molecular genetics
de Boer A,Storm A,Gomez-Soler M,Smolders S,Rué L,Poppe L,B Pasquale E,Robberecht W,Lemmens R
37-1600 was used in Western Blotting to assess the effectiveness of a basic enriched environment in the chronic phase after photothrombotic stroke in mice as well as the therapeutic potential of EphA4 targeted therapy followed by rehabilitation.
Fri Mar 13 00:00:00 EDT 2020
Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.
Acta neuropathologica
Garcia-Diaz B,Bachelin C,Coulpier F,Gerschenfeld G,Deboux C,Zujovic V,Charnay P,Topilko P,Baron-Van Evercooren A
37-1600 was used in Western Blotting to study schwann cell migratory behaviour ex vivo and in vivo after exogenous transplantation in the demyelinated spinal cord.
Sun Sep 01 00:00:00 EDT 2019
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Alzheimer's research & therapy
Poppe L,Rué L,Timmers M,Lenaerts A,Storm A,Callaerts-Vegh Z,Courtand G,de Boer A,Smolders S,Van Damme P,Van Den Bosch L,D'Hooge R,De Strooper B,Robberecht W,Lemmens R
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Thu Dec 12 00:00:00 EST 2019
Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy.
Frontiers in neuroscience
Poppe L,Smolders S,Rué L,Timmers M,Lenaerts A,Storm A,Schoonaert L,de Boer A,Van Damme P,Van Den Bosch L,Robberecht W,Lemmens R
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Fri Oct 20 00:00:00 EDT 2023
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage.
Journal of neuroinflammation
Kowalski EA,Chen J,Hazy A,Fritsch LE,Gudenschwager-Basso EK,Chen M,Wang X,Qian Y,Zhou M,Byerly M,Pickrell AM,Matson JB,Allen IC,Theus MH
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Immunofluorescence
Mon Nov 11 00:00:00 EST 2019
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage.
Journal of neuroinflammation
Kowalski EA,Chen J,Hazy A,Fritsch LE,Gudenschwager-Basso EK,Chen M,Wang X,Qian Y,Zhou M,Byerly M,Pickrell AM,Matson JB,Allen IC,Theus MH
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Immunofluorescence
Mon Nov 11 00:00:00 EST 2019
Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.
Scientific reports
Rué L,Timmers M,Lenaerts A,Smolders S,Poppe L,de Boer A,Van Den Bosch L,Van Damme P,Robberecht W,Lemmens R
37-1600 was used in Western Blotting to gain more insights in the cell-specific role of decreasing EphA4 expression in addition to timing and amount of EphA4 reduction.
Tue Oct 01 00:00:00 EDT 2019
Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.
Nature microbiology
Chen J,Sathiyamoorthy K,Zhang X,Schaller S,Perez White BE,Jardetzky TS,Longnecker R
37-1600 was used in Blocking experiments to discover EphA2 as an Epstein-Barr virus epithelial cell receptor has important implications for EBV pathogenesis and may uncover new potential targets that can be used for the development of novel intervention strategies.
Thu Feb 01 00:00:00 EST 2018
An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation.
Development (Cambridge, England)
Rothe M,Kanwal N,Dietmann P,Seigfried FA,Hempel A,Schütz D,Reim D,Engels R,Linnemann A,Schmeisser MJ,Bockmann J,Kühl M,Boeckers TM,Kühl SJ
371600 was used in western blot to show a direct interaction between Sipa1l3 and Epha4 is required for proper eye development
Sun Jan 15 00:00:00 EST 2017
Potent and Selective EphA4 Agonists for the Treatment of ALS.
Cell chemical biology
Wu B,De SK,Kulinich A,Salem AF,Koeppen J,Wang R,Barile E,Wang S,Zhang D,Ethell I,Pellecchia M
37-1600 was used in Western Blotting to report on the design and characterization of a family of EphA4 targeting agents that bind to its ligand binding domain with nanomolar affinity.
Thu Mar 16 00:00:00 EDT 2017
Eph receptor interclass cooperation is required for the regulation of cell proliferation.
Experimental cell research
Jurek A,Genander M,Kundu P,Catchpole T,He X,Strååt K,Sabelström H,Xu NJ,Pettersson S,Henkemeyer M,Frisén J
371600 was used in immunoprecipitation and western blot to describe the contributions of ephrin-B1 and ephrin-B2 to the migration and proliferation of the intestinal stem cell niche
Sat Oct 15 00:00:00 EDT 2016
The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve.
The European journal of neuroscience
Joly S,Jordi N,Schwab ME,Pernet V
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Wed Oct 01 00:00:00 EDT 2014
Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the γ-secretase inhibitor semagacestat.
American journal of neurodegenerative disease
Roher AE,Maarouf CL,Kokjohn TA,Whiteside CM,Kalback WM,Serrano G,Belden C,Liebsack C,Jacobson SA,Sabbagh MN,Beach TG
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Wed Jan 28 00:00:00 EST 2015
Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke.
Human molecular genetics
Lemmens R,Jaspers T,Robberecht W,Thijs VN
37-1600 was used in western blot to test if EphA4 affects stroke recovery and evaluate Eph44 as a therapeutic target.
Sat Jun 01 00:00:00 EDT 2013
Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.
Molecular and cellular biology
Semerdjieva S,Abdul-Razak HH,Salim SS,Yáñez-Muñoz RJ,Chen PE,Tarabykin V,Alifragis P
37-1600 was used in immunohistochemistry to investigate the role of Src-like adaptor protein in the context of NMDA receptor signaling
Mon Apr 01 00:00:00 EDT 2013
Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.
Molecular and cellular biology
Semerdjieva S,Abdul-Razak HH,Salim SS,Yáñez-Muñoz RJ,Chen PE,Tarabykin V,Alifragis P
37-1600 was used in immunohistochemistry to investigate the role of Src-like adaptor protein in the context of NMDA receptor signaling
Mon Apr 01 00:00:00 EDT 2013
Upregulation of axon guidance molecules in the adult central nervous system of Nogo-A knockout mice restricts neuronal growth and regeneration.
The European journal of neuroscience
Kempf A,Montani L,Petrinovic MM,Schroeter A,Weinmann O,Patrignani A,Schwab ME
37-1600 was used in western blot to study the increased levels of certain axon guidance proteins in the CNS of Nogo-A ablated mice and their role in limiting the outgrowth of neurites in the absence of Nogo.
Sun Dec 01 00:00:00 EST 2013
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Nature medicine
Van Hoecke A,Schoonaert L,Lemmens R,Timmers M,Staats KA,Laird AS,Peeters E,Philips T,Goris A,Dubois B,Andersen PM,Al-Chalabi A,Thijs V,Turnley AM,van Vught PW,Veldink JH,Hardiman O,Van Den Bosch L,Gonzalez-Perez P,Van Damme P,Brown RH,van den Berg LH,Robberecht W
37-1600 was used in western blot to elucidate the role of Epha4 in models of amyotrophic lateral sclerosis.
Sat Sep 01 00:00:00 EDT 2012
Profiling Eph receptor expression in cells and tissues: a targeted mass spectrometry approach.
Cell adhesion & migration
Noberini R,Rubio de la Torre E,Pasquale EB
Published figure using EphA4 monoclonal antibody (Product # 37-1600) in Western Blot
Wed Nov 28 00:00:00 EST 2012
Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction.
PloS one
Yumoto N,Wakatsuki S,Kurisaki T,Hara Y,Osumi N,Frisén J,Sehara-Fujisawa A
37-1600 was used in immunoprecipitation to test if ADAM family proteins contribute to the development of the neuromuscular junction
Thu Oct 02 00:00:00 EDT 2008
alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.
Neuron
Beg AA,Sommer JE,Martin JH,Scheiffele P
37-1600 was used in western blot to examine neuronal RacGAP alpha2-chimaerin as an effector for the receptor tyrosine kinase EphA4 in cortical and spinal motor circuits
Thu Sep 06 00:00:00 EDT 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Richter M,Murai KK,Bourgin C,Pak DT,Pasquale EB
Wed Dec 19 00:00:00 EST 2007