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Product Details
PA5-112413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Ephrin type-A receptor 5 protein (246-514AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2867148
Target Information
EPHA5 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e. g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e. g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARCC2; Brain-specific kinase; CTPA; CTPP1; ECK; EHK-1; EK7; epa5; EPH homology kinase 1; EPH-like kinase 7; Ephrin A2; Ephrin A5; Ephrin type-A receptor 5; EphrinA2; EphrinA5; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1
Gene Aliases: BSK; CEK7; EHK-1; EHK1; EK7; EPHA5; HEK7; TYRO4
UniProt ID: (Human) P54756
Entrez Gene ID: (Human) 2044
axon guidance
peptidyl-tyrosine phosphorylation
cAMP-mediated signaling
hippocampus development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
ephrin receptor signaling pathway
neuron development
regulation of insulin secretion involved in cellular response to glucose stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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