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Invitrogen
Estrogen Receptor alpha Monoclonal Antibody (TE111.5D11)
Product Details
MA1-12692
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Hamster,
Human,
Mouse,
Sheep,
Pig,
Rabbit,
Rat
Published species
Bovine,
Chicken,
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TE111.5D11
Immunogen
C-terminal fragment (aa 302-595) of human ER expressed in E coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1074278
Product Specific Information
A suggested positive control for this product is T47D cells.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686N23123; ER; Er alpha; ER-alpha; ER36; esr 1; esr-1; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; hER-alpha36; nuclear receptor; Nuclear receptor subfamily 3 group A member 1; RP1-130E4.1; unnamed protein product
Gene Aliases: ER; ER-alpha; ERa; ERALPHA; ESR; ESR1; ESRA; Estr; Estra; ESTRR; I79_001166; NR3A1; RNESTROR
UniProt ID: (Human) P03372, (Chicken) P06212, (Bovine) P49884, (Pig) Q29040, (Mouse) P19785, (Rat) P06211
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription coactivator binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
steroid binding
protein binding
beta-catenin binding
transcription factor binding
zinc ion binding
enzyme binding
nitric-oxide synthase regulator activity
estrogen receptor activity
type 1 metabotropic glutamate receptor binding
protein complex binding
estrogen response element binding
phosphatidylinositol 3-kinase regulatory subunit binding
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
hormone binding
identical protein binding
ATPase binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
sequence-specific DNA binding
Hsp90 protein binding
TFIIB-class transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
TBP-class protein binding
protein kinase binding
estrogen receptor binding
DNA binding
negative regulation of transcription from RNA polymerase II promoter
antral ovarian follicle growth
osteoblast development
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
androgen metabolic process
negative regulation of gene expression
positive regulation of phospholipase C activity
intracellular steroid hormone receptor signaling pathway
intracellular estrogen receptor signaling pathway
response to estradiol
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
regulation of neuron apoptotic process
response to estrogen
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of glucose import
decidualization
positive regulation of fibroblast proliferation
negative regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
Sertoli cell development
Sertoli cell proliferation
uterus development
vagina development
prostate epithelial cord elongation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
regulation of branching involved in prostate gland morphogenesis
mammary gland branching involved in pregnancy
mammary gland alveolus development
epithelial cell proliferation involved in mammary gland duct elongation
positive regulation of ERK1 and ERK2 cascade
protein localization to chromatin
cellular response to estrogen stimulus
cellular response to estradiol stimulus
negative regulation of triglyceride metabolic process
negative regulation of neuron death
negative regulation of production of miRNAs involved in gene silencing by miRNA
baculum development
epithelial cell development
regulation of transcription from RNA polymerase II promoter
male gonad development
intracellular receptor signaling pathway
regulation of apoptotic process
steroid hormone mediated signaling pathway
positive regulation of nitric oxide biosynthetic process
positive regulation of retinoic acid receptor signaling pathway
positive regulation of nitric-oxide synthase activity
positive regulation of gene expression
regulation of toll-like receptor signaling pathway
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
stem cell differentiation
regulation of inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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