Proteintech

FADD Polyclonal Antibody

FADD Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

FADD Antibody (14906-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HT-1080 cells using 14906-1-AP (FADD antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FADD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FADD Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14906-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 29 publications 29 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat, Sheep

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FADD Fusion Protein Ag6701 (1-208 aa encoded by BC000334)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDPFLVLLH SVSSSLSSSE LTELKFLCLG RVGKRKLERV QSGLDLFSML LEQNDLEPGH TELLRELLAS LRRHDLLRRV DDFEAGAAAG AAPGEEDLCA AFNVICDNVG KDWRRLARQL KVSDTKIDSI EDRYPRNLTE RVRESLRIWK NTEKENATVA HLVGALRSCQ MNLVADLVQE VQQARDLQNR SGAMSPMSWN SDASTSEAS (1-208 aa encoded by BC000334 )

Target Information

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Effects of Treadmill Exercise on Liver Apoptosis in Fluoride-Exposed Mice.

Biological trace element research

Liu K,Chai L,Zhao T,Zhang S,Wang J,Yu Y,Niu R,Sun Z

Fri Dec 01 00:00:00 EST 2023

Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.

Theriogenology

Zhao Y,Wang Y,Ling Z,Xue Y,Luan D,Kang J,Zhang Y,Quan F

Wed Mar 15 00:00:00 EDT 2023

PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.

European journal of medicinal chemistry

Lin H,Han H,Yang M,Wen Z,Chen Q,Ma Y,Wang X,Wang C,Yin T,Wang X,Lu G,Chen H,Qi J,Yang Y

Sun Mar 05 00:00:00 EST 2023

Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.

Experimental biology and medicine (Maywood, N.J.)

Wang W,Gu Y,Ni H,Quan Q,Guo L

Thu Jun 01 00:00:00 EDT 2023

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.

International immunopharmacology

Zhang H,Zhang X,Ling C,Liu C,Hua S,Xiong Z,Zhao H,Feng Q,Feng Z,Tang J,Hong X

Sat Apr 01 00:00:00 EDT 2023

EGFR-TNFR1 pathway in endothelial cell facilitates acute lung injury by NF-κB/MAPK-mediated inflammation and RIP3-dependent necroptosis.

International immunopharmacology

Zhang H,Zhang X,Ling C,Liu C,Hua S,Xiong Z,Zhao H,Feng Q,Feng Z,Tang J,Hong X

Sat Apr 01 00:00:00 EDT 2023

Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.

Frontiers in nutrition

Liu Y,Wei Y,Wu L,Lin X,Sun R,Chen H,Shen S,Deng G

Tue May 03 00:00:00 EDT 2022

Human breast milk-derived exosomes through inhibiting AT II cell apoptosis to prevent bronchopulmonary dysplasia in rat lung.

Journal of cellular and molecular medicine

Zhou Y,Liu Y,Xu G,Liu L,Li H,Li Y,Yin J,Wang X,Yu Z

Mon Aug 01 00:00:00 EDT 2022

Mannan-Binding Lectin Deficiency Limits Inflammation-induced Myeloid-Derived Suppressor Cells Expansion via Modulating Tumor Necrosis Factor Alpha-triggered Apoptosis.

International journal of biological sciences

Dong L,Jiang H,Chen K,Xie J,An Q,Deng F,Sun Z,Liu Y,Zhou J,Zhang L,Lu X,Wang M,Chen Z,Zou X,Zuo D

Fri Apr 15 00:00:00 EDT 2022

Astragaloside IV Inhibits the Proliferation of Human Uterine Leiomyomas by Targeting IDO1.

Cancers

Qiu T,Li D,Liu Y,Ren H,Yang X,Luo W

Mon Sep 12 00:00:00 EDT 2022

Astragaloside IV Inhibits the Proliferation of Human Uterine Leiomyomas by Targeting IDO1.

Cancers

Qiu T,Li D,Liu Y,Ren H,Yang X,Luo W

Mon Sep 12 00:00:00 EDT 2022

N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.

Cell cycle (Georgetown, Tex.)

Kang J,Wang Y,Guo X,He X,Liu W,Chen H,Wang Z,Lin A,Kang X

Tue Nov 01 00:00:00 EDT 2022

Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway.

Cell biology international

Li H,Niu N,Yang J,Dong F,Zhang T,Li S,Zhao W

Sun Aug 01 00:00:00 EDT 2021

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP_L.

Communications biology

Nakabayashi O,Takahashi H,Moriwaki K,Komazawa-Sakon S,Ohtake F,Murai S,Tsuchiya Y,Koyahara Y,Saeki Y,Yoshida Y,Yamazaki S,Tokunaga F,Sawasaki T,Nakano H

Tue Jan 19 00:00:00 EST 2021

Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats.

Ecotoxicology and environmental safety

Li H,Fan J,Zhao Y,Yang J,Xu H,Manthari RK,Cheng X,Wang J,Wang J

Wed Dec 15 00:00:00 EST 2021

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.

Cell research

Zhang JY,Zhou B,Sun RY,Ai YL,Cheng K,Li FN,Wang BR,Liu FJ,Jiang ZH,Wang WJ,Zhou D,Chen HZ,Wu Q

Wed Sep 01 00:00:00 EDT 2021

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5.

PLoS biology

Zhang Y,Huang K,Zhang Y,Han T,Li L,Ruan C,Sun YH,Shi W,Han W,Wu SQ,Song J,Liu J,Han J

Sun Aug 01 00:00:00 EDT 2021

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.

Frontiers in immunology

Miyashita H,Oikawa D,Terawaki S,Kabata D,Shintani A,Tokunaga F

Tue Sep 21 00:00:00 EDT 2021

Crosstalk Between NDP52 and LUBAC in Innate Immune Responses, Cell Death, and Xenophagy.

Frontiers in immunology

Miyashita H,Oikawa D,Terawaki S,Kabata D,Shintani A,Tokunaga F

Tue Sep 21 00:00:00 EDT 2021

Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.

Biochemical pharmacology

Liu X,Zhang Y,Wu S,Xu M,Shen Y,Yu M,Fan J,Wei S,Xu C,Huang L,Zhao H,Li X,Ye X

Fri May 01 00:00:00 EDT 2020

Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.

Cell proliferation

Peng F,Zhang N,Wang C,Wang X,Huang W,Peng C,He G,Han B

Wed Jan 01 00:00:00 EST 2020

Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.

Life sciences

Gao L,Qian B,Chen H,Wang A,Li Q,Li J,Tan P,Xia X,Du Y,Fu W

Fri May 15 00:00:00 EDT 2020

Protective effect of astaxanthin against SnS₂ nanoflowers induced testes toxicity by suppressing RIPK1-RIPK3-MLKL signaling in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Yuan L,Liang P,Qu Y,An T,Wang J,Deng X,Bai L,Shen P,Bai D

Sun Nov 01 00:00:00 EDT 2020

ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.

Environmental toxicology

Liu C,Zhang A

Thu Oct 01 00:00:00 EDT 2020

Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.

Life sciences

Wang B,Xu H,Hu X,Ma W,Zhang J,Li Y,Yu M,Zhang Y,Li X,Ye X

Sun Mar 15 00:00:00 EDT 2020

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

International journal of molecular sciences

Zhao Q,Zhu HP,Xie X,Mao Q,Liu YQ,He XH,Peng C,Jiang QL,Huang W

Sat Mar 07 00:00:00 EST 2020

SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.

Experimental cell research

Tan P,Wang A,Chen H,Du Y,Qian B,Shi H,Zhang Y,Xia X,Fu W

Fri Nov 01 00:00:00 EDT 2019

SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis.

Experimental cell research

Tan P,Wang A,Chen H,Du Y,Qian B,Shi H,Zhang Y,Xia X,Fu W

Fri Nov 01 00:00:00 EDT 2019

Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.

OncoTargets and therapy

Xu W,Hu GQ,Da Costa C,Tang JH,Li QR,Du L,Pan YW,Lv SQ

Thu Oct 01 00:00:00 EDT 2020

Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR_L and inhibit apoptosis in human non-small cell lung cancer cells.

Journal of experimental & clinical cancer research : CR

An W,Yao S,Sun X,Hou Z,Lin Y,Su L,Liu X

Thu May 02 00:00:00 EDT 2019

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.

Oncology reports

Zhan Y,Zhang H,Dai B,Zhang Y,Zhang J,He L

Wed Aug 01 00:00:00 EDT 2018

A novel biphenyl urea compound, TPD7, stimulates apoptosis through modulating Fas signaling and Bcl-2 family proteins in cervical cancer.

Oncology reports

Zhan Y,Zhang H,Dai B,Zhang Y,Zhang J,He L

Wed Aug 01 00:00:00 EDT 2018

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

Oxidative medicine and cellular longevity

Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

Thu Apr 20 00:00:00 EDT 2017

Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.

Oxidative medicine and cellular longevity

Jiang Z,Song F,Li Y,Xue D,Zhao N,Zhang J,Deng G,Li M,Liu X,Wang Y

Thu Apr 20 00:00:00 EDT 2017

Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells.

Cellular microbiology

Liu X,Ding S,Shi P,Dietrich R,Märtlbauer E,Zhu K

Sat Apr 01 00:00:00 EDT 2017

Non-hemolytic enterotoxin of Bacillus cereus induces apoptosis in Vero cells.

Cellular microbiology

Liu X,Ding S,Shi P,Dietrich R,Märtlbauer E,Zhu K

Sat Apr 01 00:00:00 EDT 2017

Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Brain injury

Zhang HB,Cheng SX,Tu Y,Zhang S,Hou SK,Yang Z

Tue Jan 09 00:00:00 EST 2018

Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Brain injury

Zhang HB,Cheng SX,Tu Y,Zhang S,Hou SK,Yang Z

Tue Jan 09 00:00:00 EST 2018

Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Brain injury

Zhang HB,Cheng SX,Tu Y,Zhang S,Hou SK,Yang Z

Tue Jan 09 00:00:00 EST 2018

Protective effect of mild-induced hypothermia against moderate traumatic brain injury in rats involved in necroptotic and apoptotic pathways.

Brain injury

Zhang HB,Cheng SX,Tu Y,Zhang S,Hou SK,Yang Z

Tue Jan 09 00:00:00 EST 2018

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.

Hepatology communications

Hirsova P,Weng P,Salim W,Bronk SF,Griffith TS,Ibrahim SH,Gores GJ

Fri Sep 01 00:00:00 EDT 2017

TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.

Hepatology communications

Hirsova P,Weng P,Salim W,Bronk SF,Griffith TS,Ibrahim SH,Gores GJ

Fri Sep 01 00:00:00 EDT 2017

Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis.

Apoptosis : an international journal on programmed cell death

Wang Y,Huang ZH,Li YJ,He GW,Yu RY,Yang J,Liu WT,Li B,He QY

Thu Dec 01 00:00:00 EST 2016

Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis.

Apoptosis : an international journal on programmed cell death

Wang Y,Huang ZH,Li YJ,He GW,Yu RY,Yang J,Liu WT,Li B,He QY

Thu Dec 01 00:00:00 EST 2016

miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells.

Molecular and cellular biochemistry

Zhu GF,Yang LX,Guo RW,Liu H,Shi YK,Wang H,Ye JS,Yang ZH,Liang X

Tue Oct 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; Growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; protein FADD

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Gene Aliases: FADD; GIG3; MORT1; Mort1/FADD

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UniProt ID: (Human) Q13158, (Mouse) Q61160

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Entrez Gene ID: (Human) 8772, (Mouse) 14082, (Rat) 266610

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Function(s)

protease binding death receptor binding tumor necrosis factor receptor binding protein binding protein complex binding tumor necrosis factor receptor superfamily binding death effector domain binding identical protein binding caspase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FADD Polyclonal Antibody

FADD Antibody (14906-1-AP) in ICC/IF

Product Details

14906-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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