Proteintech

FAF2 Polyclonal Antibody

FAF2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 27

FAF2 Antibody (16251-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells using 16251-1-AP (FAF2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

FAF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FAF2 Antibody in Immunoprecipitation (IP)

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Product Details

16251-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FAF2 Fusion Protein Ag9236 (97-445 aa encoded by BC014001)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YLIMLPFRF TYYTILDIFR FALRFIRPDP RSRVTDPVGD IVSFMHSFEE KYGRAHPVFY QGTYSQALND AKRELRFLLV YLHGDDHQDS DEFCRNTLCA PEVISLINTR MLFWACSTNK PEGYRVSQAL RENTYPFLAM IMLKDRRMTV VGRLEGLIQP DDLINQLTFI MDANQTYLVS ERLEREERNQ TQVLRQQQDE AYLASLRADQ EKERKKREER ERKRRKEEEV QQQKLAEERR RQNLQEEKER KLECLPPEPS PDDPESVKII FKLPNDSRVE RRFHFSQSLT VIHDFLFSLK ESPEKFQIEA NFPRRVLPCI PSEEWPNPPT LQEAGLSHTE VLFVQDLTDE (97-445 aa encoded by BC014001)

Target Information

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.

The Journal of cell biology

Jaffray EG,Tatham MH,Mojsa B,Liczmanska M,Rojas-Fernandez A,Yin Y,Ball G,Hay RT

Mon Apr 03 00:00:00 EDT 2023

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

Research (Washington, D.C.)

Wang F,Wang L,Gan S,Feng S,Ouyang S,Wang X,Yuan S

Thu May 25 00:00:00 EDT 2023

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.

Research (Washington, D.C.)

Wang F,Wang L,Gan S,Feng S,Ouyang S,Wang X,Yuan S

Thu May 25 00:00:00 EDT 2023

The p97-UBXD8 complex regulates ER-Mitochondria contact sites by altering membrane lipid saturation and composition.

Nature communications

Ganji R,Paulo JA,Xi Y,Kline I,Zhu J,Clemen CS,Weihl CC,Purdy JG,Gygi SP,Raman M

Mon Feb 06 00:00:00 EST 2023

Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma.

Nature metabolism

Liu F,Tian T,Zhang Z,Xie S,Yang J,Zhu L,Wang W,Shi C,Sang L,Guo K,Yang Z,Qu L,Liu X,Liu J,Yan Q,Ju HQ,Wang W,Piao HL,Shao J,Zhou T,Lin A

Mon Aug 01 00:00:00 EDT 2022

Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma.

Nature metabolism

Liu F,Tian T,Zhang Z,Xie S,Yang J,Zhu L,Wang W,Shi C,Sang L,Guo K,Yang Z,Qu L,Liu X,Liu J,Yan Q,Ju HQ,Wang W,Piao HL,Shao J,Zhou T,Lin A

Mon Aug 01 00:00:00 EDT 2022

UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.

EMBO reports

Zheng J,Cao Y,Yang J,Jiang H

Thu Oct 06 00:00:00 EDT 2022

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

Science (New York, N.Y.)

Gwon Y,Maxwell BA,Kolaitis RM,Zhang P,Kim HJ,Taylor JP

Fri Jun 25 00:00:00 EDT 2021

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner.

Science (New York, N.Y.)

Gwon Y,Maxwell BA,Kolaitis RM,Zhang P,Kim HJ,Taylor JP

Fri Jun 25 00:00:00 EDT 2021

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.

eLife

Fenech EJ,Lari F,Charles PD,Fischer R,Laétitia-Thézénas M,Bagola K,Paton AW,Paton JC,Gyrd-Hansen M,Kessler BM,Christianson JC

Thu Jul 02 00:00:00 EDT 2020

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.

Molecular and cellular biology

Ganji R,Mukkavalli S,Somanji F,Raman M

Sun Jul 01 00:00:00 EDT 2018

The VCP-UBXN1 Complex Mediates Triage of Ubiquitylated Cytosolic Proteins Bound to the BAG6 Complex.

Molecular and cellular biology

Ganji R,Mukkavalli S,Somanji F,Raman M

Sun Jul 01 00:00:00 EDT 2018

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.

Molecular biology of the cell

Huang EY,To M,Tran E,Dionisio LTA,Cho HJ,Baney KLM,Pataki CI,Olzmann JA

Tue May 01 00:00:00 EDT 2018

A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.

Molecular biology of the cell

Huang EY,To M,Tran E,Dionisio LTA,Cho HJ,Baney KLM,Pataki CI,Olzmann JA

Tue May 01 00:00:00 EDT 2018

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

Molecular biology of the cell

To M,Peterson CW,Roberts MA,Counihan JL,Wu TT,Forster MS,Nomura DK,Olzmann JA

Sun Jan 15 00:00:00 EST 2017

Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

Molecular biology of the cell

To M,Peterson CW,Roberts MA,Counihan JL,Wu TT,Forster MS,Nomura DK,Olzmann JA

Sun Jan 15 00:00:00 EST 2017

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

Molecular biology of the cell

Zhang T,Xu Y,Liu Y,Ye Y

Tue Dec 01 00:00:00 EST 2015

gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.

Molecular biology of the cell

Zhang T,Xu Y,Liu Y,Ye Y

Tue Dec 01 00:00:00 EST 2015

Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.

The Journal of biological chemistry

Lee JG,Kim W,Gygi S,Ye Y

Fri Feb 07 00:00:00 EST 2014

Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.

The Journal of biological chemistry

Lee JG,Kim W,Gygi S,Ye Y

Fri Feb 07 00:00:00 EST 2014

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

eLife

Liu Y,Soetandyo N,Lee JG,Liu L,Xu Y,Clemons WM,Ye Y

Wed Feb 10 00:00:00 EST 2016

USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

eLife

Liu Y,Soetandyo N,Lee JG,Liu L,Xu Y,Clemons WM,Ye Y

Wed Feb 10 00:00:00 EST 2016

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

The Journal of biological chemistry

Xu Y,Liu Y,Lee JG,Ye Y

Fri Jun 21 00:00:00 EDT 2013

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

The Journal of biological chemistry

Xu Y,Liu Y,Lee JG,Ye Y

Fri Jun 21 00:00:00 EDT 2013

A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.

The Journal of biological chemistry

Xu Y,Liu Y,Lee JG,Ye Y

Fri Jun 21 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: expressed in T-cells and eosinophils in atopic dermatitis; FAS-associated factor 2; protein expressed in T-cells and eosinophils in atopic dermatitis; UBX domain containing 8; UBX domain protein 3B; UBX domain-containing protein 3B; UBX domain-containing protein 8

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Gene Aliases: 2210404D11Rik; AI462440; ETEA; FAF2; KIAA0887; mKIAA0887; RGD1306577; UBXD8; UBXN3B

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UniProt ID: (Human) Q96CS3, (Rat) Q5BK32, (Mouse) Q3TDN2

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Entrez Gene ID: (Human) 23197, (Rat) 291000, (Mouse) 76577

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Function(s)

protein binding ubiquitin protein ligase binding lipase binding ubiquitin binding lipase inhibitor activity

Process(es)

response to unfolded protein lipid particle organization negative regulation of catalytic activity ER-associated ubiquitin-dependent protein catabolic process retrograde protein transport, ER to cytosol

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FAF2 Polyclonal Antibody

FAF2 Antibody (16251-1-AP) in ICC/IF

Product Details

16251-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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