Invitrogen

FAK Polyclonal Antibody

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

38 Published Figures

42 References

View all (102) FAK antibodies

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FAK Antibody (AHO0502) in WB

CRISPR-Cas9 mediated genome editing ofFAK (as confirmed by next generation sequencing) was achieved by using LentiArray™ Lentiviral sgRNA (Product # A32042, AssayID CRISPR627416_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Fig (a) Western blot analysis of FAK was performed by loading 30 µg of A549 wild type (Lane 1), A549 Cas9 (Lane 2) and A549 Cas9 cells transduced with FAK Lentiviral sgRNA (Lane 3) membrane enriched extracts. The samples were electrophoresed using NuPAGE™ 3 to 8%, Tris-Acetate, 1.0 mm, Mini Protein Gel (Product... View More

FAK Antibody in Immunocytochemistry (ICC/IF)

FAK Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF)

FAK Antibody in Western Blot, Immunoprecipitation (WB, IP)

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FAK Antibody — Focal Adhesion Kinase (FAK) Protein Schematic-Focal Adhesion Kinase (FAK) is a non-receptor protein tyrosine kinase discovered as a substrate for Src and as a key element of integrin signaling. FAK plays a central role in cell spreading, differentiation, migration, cell death and acceleration of the G1 to S phase transition of the cell cycle. FAK regulation includes phosphorylation at multiple tyrosine and serine residues. Phosphorylation of tyrosine generally is associated with positive regulation and growth promotion; however, dephosphorylation at these sites occurs as cells enter mitosis (M-Phase of the cell cycle). In contrast, serine phosphorylation either remains high or is increased as cells enter mitosis. (Product # 44-626G).

Product Details

AHO0502

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 30 publications 30 publications

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

Assay-dependent

View 4 publications 4 publications

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to amino acid residues 853-1052 from theC-terminal region of human FAK.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.2% BSA

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2536313

Target Information

Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors. Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin. Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase. In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin. In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis. Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

KCNF1 promotes lung cancer by modulating ITGB4 expression.

Cancer gene therapy

Chen CY,Wu PY,Van Scoyk M,Simko SA,Chou CF,Winn RA

AHO0502 was used in Western Blotting to suggest that KCNF1 promotes lung cancer by enhancing ITGB4 signaling and implicate KCNF1 as a novel therapeutic target for lung cancer.

Wed Mar 01 00:00:00 EST 2023

KCNF1 promotes lung cancer by modulating ITGB4 expression.

Cancer gene therapy

Chen CY,Wu PY,Van Scoyk M,Simko SA,Chou CF,Winn RA

AHO0502 was used in Western Blotting to suggest that KCNF1 promotes lung cancer by enhancing ITGB4 signaling and implicate KCNF1 as a novel therapeutic target for lung cancer.

Wed Mar 01 00:00:00 EST 2023

Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes.

Journal of molecular endocrinology

Mäkinen S,Datta N,Rangarajan S,Nguyen YH,Olkkonen VM,Latva-Rasku A,Nuutila P,Laakso M,Koistinen HA

AHO0502 was used in Western Blotting to show that myotubes from p.P50T/AKT2 variant carriers show multiple signalling alterations which may contribute to predisposition to insulin resistance and T2D in the carriers of this signalling variant.

Wed Feb 01 00:00:00 EST 2023

Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds.

Biomedicines

Betriu N,Andreeva A,Alonso A,Semino CE

AHO0502 was used in Western Blotting to highlight how cell response to increased matrix stiffness greatly depends on the nature of the matrix used for 3D culture.

Fri Jul 29 00:00:00 EDT 2022

Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds.

Biomedicines

Betriu N,Andreeva A,Alonso A,Semino CE

AHO0502 was used in Western Blotting to highlight how cell response to increased matrix stiffness greatly depends on the nature of the matrix used for 3D culture.

Fri Jul 29 00:00:00 EDT 2022

The Synergistic Effect of Cyclic Tensile Force and Periodontal Ligament Cell-Laden Calcium Silicate/Gelatin Methacrylate Auxetic Hydrogel Scaffolds for Bone Regeneration.

Cells

Lee JJ,Ng HY,Lin YH,Lin TJ,Kao CT,Shie MY

AHO0502 was used in Western Blotting to show that novel auxetic scaffolds could be fabricated by combining different aspects of science and technology, in order to improve the future chances of clinical applications for bone regeneration.

Wed Jun 29 00:00:00 EDT 2022

Mechanical Loading Disrupts Focal Adhesion Kinase Activation in Mandibular Fibrochondrocytes During Murine Temporomandibular Joint Osteoarthritis.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Reed DA,Zhao Y,Han M,Mercuri LG,Miloro M

AHO0502 was used in Western Blot to hypothesize that mechanical overloading disrupts TMJ homeostasis through dysregulation of FAK signaling.

Fri Oct 01 00:00:00 EDT 2021

EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK.

Cells

Chanez B,Ostacolo K,Badache A,Thuault S

AHO0502 was used in Western Blotting to propose that EB1 restricts invadopodia formation through the control of FAK and, consequently, the spatial regulation of Src activity.

Sat Feb 13 00:00:00 EST 2021

EB1 Restricts Breast Cancer Cell Invadopodia Formation and Matrix Proteolysis via FAK.

Cells

Chanez B,Ostacolo K,Badache A,Thuault S

AHO0502 was used in Western Blotting to propose that EB1 restricts invadopodia formation through the control of FAK and, consequently, the spatial regulation of Src activity.

Sat Feb 13 00:00:00 EST 2021

Dexamethasone accelerates muscle regeneration by modulating kinesin-1-mediated focal adhesion signals.

Cell death discovery

Lin JW,Huang YM,Chen YQ,Chuang TY,Lan TY,Liu YW,Pan HW,You LR,Wang YK,Lin KH,Chiou A,Kuo JC

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Wed Feb 17 00:00:00 EST 2021

Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway.

OncoTargets and therapy

BommaReddy RR,Patel R,Smalley T,Acevedo-Duncan M

Published figure using FAK polyclonal antibody (Product # AHO0502) in Immunoprecipitation

Wed Apr 13 00:00:00 EDT 2022

Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway.

OncoTargets and therapy

BommaReddy RR,Patel R,Smalley T,Acevedo-Duncan M

Published figure using FAK polyclonal antibody (Product # AHO0502) in Immunoprecipitation

Wed Apr 13 00:00:00 EDT 2022

Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.

Communications biology

Atsumi S,Katoh H,Komura D,Hashimoto I,Furuya G,Koda H,Konishi H,Suzuki R,Yamamoto A,Yuba S,Abe H,Rino Y,Oshima T,Ushiku T,Fukayama M,Seto Y,Ishikawa S

AHO0502 was used in Western Blot, Immunoprecipitation to show that B-cell repertoire sequencing of 102 clinical gastric cancers and molecular biological analyses unexpectedly reveal that the major humoral cancer antigens are not case-specific neo-antigens but are rather commonly identified as ribonucleoproteins (RNPs) in the focal adhesion complex.

Fri Oct 16 00:00:00 EDT 2020

Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.

Communications biology

Atsumi S,Katoh H,Komura D,Hashimoto I,Furuya G,Koda H,Konishi H,Suzuki R,Yamamoto A,Yuba S,Abe H,Rino Y,Oshima T,Ushiku T,Fukayama M,Seto Y,Ishikawa S

Fri Oct 16 00:00:00 EDT 2020

Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.

Communications biology

Atsumi S,Katoh H,Komura D,Hashimoto I,Furuya G,Koda H,Konishi H,Suzuki R,Yamamoto A,Yuba S,Abe H,Rino Y,Oshima T,Ushiku T,Fukayama M,Seto Y,Ishikawa S

Fri Oct 16 00:00:00 EDT 2020

Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases.

Communications biology

Atsumi S,Katoh H,Komura D,Hashimoto I,Furuya G,Koda H,Konishi H,Suzuki R,Yamamoto A,Yuba S,Abe H,Rino Y,Oshima T,Ushiku T,Fukayama M,Seto Y,Ishikawa S

Fri Oct 16 00:00:00 EDT 2020

Formin mDia1 contributes to migration and epithelial-mesenchymal transition of tubular epithelial cells exposed to TGF-β1.

Journal of cellular biochemistry

Li YY,Jiang GT,Chen LJ,Jiang YH,Jiao JD

AHO0502 was used in Western Blotting to explore the role of mDia1 in EMT of tubular epithelial cells.

Sat Aug 01 00:00:00 EDT 2020

Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.

American journal of physiology. Renal physiology

Raman A,Parnell SC,Zhang Y,Reif GA,Dai Y,Khanna A,Daniel E,White C,Vivian JL,Wallace DP

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Sat Dec 01 00:00:00 EST 2018

Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation.

PloS one

Böhm BB,Fehrl Y,Janczi T,Schneider N,Burkhardt H

AHO0502 was used in Western Blotting to study the regulatory role of ADAM15 on mRNA translation at the cell membrane, and potential implications under pathologic conditions of matrix remodelling associated with ADAM15 upregulation.

Fri Mar 22 00:00:00 EDT 2019

Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation.

PloS one

Böhm BB,Fehrl Y,Janczi T,Schneider N,Burkhardt H

Fri Mar 22 00:00:00 EDT 2019

Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity.

Journal of cell science

Atherton P,Lausecker F,Harrison A,Ballestrem C

AHO0502 was used in Western Blotting to demonstrate that a similar focal adhesion kinase-Rab5-Rac1 pathway acts to control cell spreading upon fibronectin.

Sat Jul 15 00:00:00 EDT 2017

Fibronectin in cell adhesion and migration via N-glycosylation.

Oncotarget

Hsiao CT,Cheng HW,Huang CM,Li HR,Ou MH,Huang JR,Khoo KH,Yu HW,Chen YQ,Wang YK,Chiou A,Kuo JC

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Tue Sep 19 00:00:00 EDT 2017

A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.

Stem cell reports

Jaraíz-Rodríguez M,Tabernero MD,González-Tablas M,Otero A,Orfao A,Medina JM,Tabernero A

AHO0502 was used in Western Blotting to show that a cell-penetrating peptide inhibited c-Src and focal adhesion kinase, and upregulated phosphatase and tensin homolog in glioma stem cells derived from patients.

Tue Aug 08 00:00:00 EDT 2017

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.

Scientific reports

Ungewiss C,Rizvi ZH,Roybal JD,Peng DH,Gold KA,Shin DH,Creighton CJ,Gibbons DL

Published figure using FAK polyclonal antibody (Product # AHO0502) in Immunofluorescence

Tue Jan 05 00:00:00 EST 2016

The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL.

Scientific reports

Ungewiss C,Rizvi ZH,Roybal JD,Peng DH,Gold KA,Shin DH,Creighton CJ,Gibbons DL

Published figure using FAK polyclonal antibody (Product # AHO0502) in Immunofluorescence

Tue Jan 05 00:00:00 EST 2016

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.

Scientific reports

Wu JC,Chen YC,Kuo CT,Wenshin Yu H,Chen YQ,Chiou A,Kuo JC

AHO0502 was used in western blot to test if SRC, SHP1, and SHP2 target focal adhesions via their SH2 domains

Fri Dec 18 00:00:00 EST 2015

Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration.

Scientific reports

Wu JC,Chen YC,Kuo CT,Wenshin Yu H,Chen YQ,Chiou A,Kuo JC

AHO0502 was used in western blot to test if SRC, SHP1, and SHP2 target focal adhesions via their SH2 domains

Fri Dec 18 00:00:00 EST 2015

MicroRNA miR-125a-3p modulates molecular pathway of motility and migration in prostate cancer cells.

Oncoscience

Ninio-Many L,Grossman H,Levi M,Zilber S,Tsarfaty I,Shomron N,Tuvar A,Chuderland D,Stemmer SM,Ben-Aharon I,Shalgi R

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Fri Jan 16 00:00:00 EST 2015

microRNA-125a-3p reduces cell proliferation and migration by targeting Fyn.

Journal of cell science

Ninio-Many L,Grossman H,Shomron N,Chuderland D,Shalgi R

AHO0502 was used in western blot to study the post-transcription regulation of Fyn by miR-25a-3p.

Mon Jul 01 00:00:00 EDT 2013

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

The Journal of biological chemistry

Kline ER,Shupe J,Gilbert-Ross M,Zhou W,Marcus AI

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Fri Jun 14 00:00:00 EDT 2013

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

The Journal of biological chemistry

Kline ER,Shupe J,Gilbert-Ross M,Zhou W,Marcus AI

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Fri Jun 14 00:00:00 EDT 2013

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

The Journal of biological chemistry

Kline ER,Shupe J,Gilbert-Ross M,Zhou W,Marcus AI

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Fri Jun 14 00:00:00 EDT 2013

LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

The Journal of biological chemistry

Kline ER,Shupe J,Gilbert-Ross M,Zhou W,Marcus AI

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Fri Jun 14 00:00:00 EDT 2013

Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Orlando C,Ster J,Gerber U,Fawcett JW,Raineteau O

AHO0502 was used in Immunocytochemistry-immunoflourescence to assess the effect of chondroitinase ABC-mediated digestion of chondroitin sulphate proteoglycans on dendritic spine dynamics.

Wed Dec 12 00:00:00 EST 2012

Enhanced integrin mediated signaling and cell cycle progression on fibronectin mimetic peptide amphiphile monolayers.

Langmuir : the ACS journal of surfaces and colloids

Shroff K,Pearce TR,Kokkoli E

AHO0502 was used in western blot to study the binding affinity of the PR_b peptide ligand with the α(5)β() integrin.

Tue Jan 24 00:00:00 EST 2012

Enhanced integrin mediated signaling and cell cycle progression on fibronectin mimetic peptide amphiphile monolayers.

Langmuir : the ACS journal of surfaces and colloids

Shroff K,Pearce TR,Kokkoli E

AHO0502 was used in western blot to study the binding affinity of the PR_b peptide ligand with the α(5)β() integrin.

Tue Jan 24 00:00:00 EST 2012

Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.

The Journal of biological chemistry

Hance MW,Dole K,Gopal U,Bohonowych JE,Jezierska-Drutel A,Neumann CA,Liu H,Garraway IP,Isaacs JS

AHO0502 was used in western blot to show a role for eHsp90 in driving epithelial to mesenchymal transition events in prostate cancer.

Fri Nov 02 00:00:00 EDT 2012

Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Tan CL,Kwok JC,Patani R,Ffrench-Constant C,Chandran S,Fawcett JW

AHO0502 was used in immunocytochemistry to test if chondroitin sulfate proteoglycans inhibit regeneration in the central nervous system by inactivating integrins.

Wed Apr 27 00:00:00 EDT 2011

Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Tan CL,Kwok JC,Patani R,Ffrench-Constant C,Chandran S,Fawcett JW

AHO0502 was used in immunocytochemistry to test if chondroitin sulfate proteoglycans inhibit regeneration in the central nervous system by inactivating integrins.

Wed Apr 27 00:00:00 EDT 2011

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.

BMC cancer

Bohonowych JE,Peng S,Gopal U,Hance MW,Wing SB,Argraves KM,Lundgren K,Isaacs JS

AHO0502 was used in western blot to discuss the use of the Hsp90 inhibitor 7-AAG in clinical trials.

Thu Dec 15 00:00:00 EST 2011

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.

BMC cancer

Bohonowych JE,Peng S,Gopal U,Hance MW,Wing SB,Argraves KM,Lundgren K,Isaacs JS

AHO0502 was used in western blot to discuss the use of the Hsp90 inhibitor 7-AAG in clinical trials.

Thu Dec 15 00:00:00 EST 2011

Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics.

Oncogene

Garamszegi N,Garamszegi SP,Samavarchi-Tehrani P,Walford E,Schneiderbauer MM,Wrana JL,Scully SP

AHO0502 was used in western blot to elucidate TGF-beta receptor dynamics and consequential signaling

Thu Apr 22 00:00:00 EDT 2010

Mesenchymal/stromal gene expression signature relates to basal-like breast cancers, identifies bone metastasis and predicts resistance to therapies.

PloS one

Marchini C,Montani M,Konstantinidou G,Orrù R,Mannucci S,Ramadori G,Gabrielli F,Baruzzi A,Berton G,Merigo F,Fin S,Iezzi M,Bisaro B,Sbarbati A,Zerani M,Galiè M,Amici A

AHO0502 was used in western blot to discuss using mesenchymalization of carcinomas as a diagnostic factor.

Tue Nov 30 00:00:00 EST 2010

Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization.

Experimental cell research

Klees RF,Salasznyk RM,Ward DF,Crone DE,Williams WA,Harris MP,Boskey A,Quaranta V,Plopper GE

AHO0502 was used in western blot to study the role of laminins during osteogenic differentiation of human mesenchymal stem cells

Fri Feb 15 00:00:00 EST 2008

Quantitative multicolor compositional imaging resolves molecular domains in cell-matrix adhesions.

PloS one

Zamir E,Geiger B,Kam Z

Published figure using FAK polyclonal antibody (Product # AHO0502) in Immunocytochemistry

Wed Apr 02 00:00:00 EDT 2008

Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5.

Journal of cellular biochemistry

Salasznyk RM,Klees RF,Boskey A,Plopper GE

Published figure using FAK polyclonal antibody (Product # AHO0502) in Western Blot

Thu Feb 01 00:00:00 EST 2007

Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells.

Experimental cell research

Salasznyk RM,Klees RF,Williams WA,Boskey A,Plopper GE

AHO0502 was used in western blot to investigate FAK signaling in the regulation of extracellular matrix-induced osteogenic differentiation of human mesenchymal stem cells

Mon Jan 01 00:00:00 EST 2007

Analyzing FAK and Pyk2 in early integrin signaling events.

Current protocols in cell biology

Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D

Sat Apr 01 00:00:00 EST 2006

Analyzing FAK and Pyk2 in early integrin signaling events.

Current protocols in cell biology

Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D

Sat Apr 01 00:00:00 EST 2006

Bioinformatics

Protein Aliases: EC 2.7.10.2; FADK 1; FAK-related non-kinase polypeptide; Focal adhesion kinase 1; focal adhesion kinase isoform FAK-Del33; Focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; p125FAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2

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Gene Aliases: FADK; FAK; FAK1; FRNK; Kiaa4203; mKIAA4203; p125FAK; pp125FAK; PPP1R71; PTK2

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UniProt ID: (Human) Q05397, (Mouse) Q5DTH7, (Rat) O35346

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Entrez Gene ID: (Human) 5747, (Mouse) 14083, (Rat) 25614

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Function(s)

actin binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity Ras guanyl-nucleotide exchange factor activity receptor binding protein binding ATP binding JUN kinase binding protein kinase binding SH2 domain binding nucleotide binding integrin binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein complex binding identical protein binding phosphatidylinositol 3-kinase binding

Process(es)

Performance Guarantee

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FAK Polyclonal Antibody

FAK Antibody (AHO0502) in WB

Product Details

AHO0502

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Functional Assay (Functional)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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