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Product Details
14366-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FAM175A Fusion Protein Ag5688 (1-300 aa encoded by BC039573)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTFRERLLH KNLQEHFSNQ DLVFLLLTPS IITESCSTHR LEHSLYKPQK GLFHRVPLVV ANLGMSEQLG YKTVSGSCMS TGFSRAVQTH SSKFFEEDGS LKEVHKINEM YASLQEELKS ICKKVEDSEQ AVDKLVKDVN RLKREIEKRR GAQIQAAREK NIQKDPQENI FLCQALRTFF PNSEFLHSCV MSLKNRHVSK SSCNYNHHLD VVDNLTLMVE HTDIPEASPA STPQIIKHKA LDLDDRWQFK RSRLLDTQDK RSKADTGSSN QDKASKMSSP ETDEEIEKMK GFGEYSRSPT F (1-300 aa encoded by BC039573)
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: abraxas protein; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A
Gene Aliases: 3830405G04Rik; 5630400M01Rik; ABRA1; ABRAXAS1; AI506069; AL024423; AV118690; CCDC98; FAM175A; RGD1305287; UNQ496/PRO1013
UniProt ID: (Human) Q6UWZ7, (Mouse) Q8BPZ8, (Rat) Q5I0F1
Entrez Gene ID: (Human) 84142, (Mouse) 70681, (Rat) 289468
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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