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Product Details
PA5-22706
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Dog,
Human,
Marsupial,
Mouse,
Non-human primate,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human FANCD2 fusion protein (N-terminal fragment).
Conjugate
Excitation/Emission Max
492/519 nm
View spectra
Form
Liquid
Concentration
0.65 mg/mL
Purification
Affinity chromatography
Storage buffer
50mM sodium borate
Contains
0.05% sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154117
Product Specific Information
In Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form).
Additional bands may be seen at lower molecular weights.
In immunofluorescence, this has been tested in human MMC and IR-treated MEF cells.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762A223; FACD2; Fancd2; Fanconi anemia complementation group D2; Fanconi anemia D2 protein; Fanconi anemia group D2 protein; Fanconi anemia group D2 protein homolog; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
Gene Aliases: 2410150O07Rik; AU015151; BB137857; FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9, (Mouse) Q80V62, (Rat) Q6IV68
Entrez Gene ID: (Dog) 484659, (Human) 2177, (Mouse) 211651, (Rat) 312641, (Zebrafish) 394241
DNA repair
cellular response to DNA damage stimulus
cell cycle
synapsis
multicellular organism development
gamete generation
response to gamma radiation
intra-S DNA damage checkpoint
interstrand cross-link repair
negative regulation of apoptotic process
double-strand break repair involved in meiotic recombination
biological_process
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