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Product Details
H00002191-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2F2
Immunogen
FAP (AAH26250, 525 a.a. approximately 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PPQFDRSKKY PLLIQVYGGP CSQSVRSVFA VNWISYLASK EGMVIALVDG RGTAFQGDKL LYAVYRKLGV YEVEDQITAV RKFIEMGFID EKRIAIWGWS
Target Information
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Fibroblast activation protein alpha; fibroblast activation protein, alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Prolyl endopeptidase FAP; Seprase; Serine integral membrane protease; SIMP; Surface-expressed protease
Gene Aliases: DPPIV; FAP; FAPA; SIMP
UniProt ID: (Human) Q12884
Entrez Gene ID: (Human) 2191
angiogenesis
proteolysis
cell adhesion
regulation of collagen catabolic process
negative regulation of extracellular matrix disassembly
endothelial cell migration
proteolysis involved in cellular protein catabolic process
regulation of fibrinolysis
negative regulation of cell proliferation involved in contact inhibition
positive regulation of cell cycle arrest
mitotic cell cycle arrest
melanocyte proliferation
positive regulation of execution phase of apoptosis
melanocyte apoptotic process
negative regulation of extracellular matrix organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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