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Product Details
H00002200-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3H6
Immunogen
FBN1 (NP_000129, 2772 a.a. approximately 2871 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: SNKVRILELL PALTTLTNHN RYLIESGNED GFFKINQKEG ISYLHFTKKK PVAGTYSLQI SSTPLYKKKE LNQLEDKYDK DYLSGELGDN LKMKIQVLLH
Target Information
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibrillin 15; Fibrillin-1
Gene Aliases: ACMICD; ECTOL1; FBN; FBN1; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; WMS; WMS2
UniProt ID: (Human) P35555
Entrez Gene ID: (Human) 2200
skeletal system development
metanephros development
heart development
extracellular matrix disassembly
extracellular matrix organization
sequestering of BMP in extracellular matrix
sequestering of TGFbeta in extracellular matrix
camera-type eye development
embryonic eye morphogenesis
post-embryonic eye morphogenesis
cellular response to transforming growth factor beta stimulus
regulation of cellular response to growth factor stimulus
cellular response to insulin-like growth factor stimulus
Performance Guarantee
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